Reactome | CYP2R1 25-hydroxylates VD3 to 25(OH)D

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CYP2R1 25-hydroxylates VD3 to 25(OH)D Show undefined attributes

catalystActivity	[CatalystActivity:10006243] vitamin D3 25-hydroxylase activity of CYP2R1 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10006245
displayName	CYP2R1 25-hydroxylates VD3 to 25(OH)D
eventOf	[Pathway:R-MMU-211916] Vitamins - Mus musculus [Pathway:R-MMU-196791] Vitamin D (calciferol) metabolism - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-209868] CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D - Mus musculus
inferredFrom	[Reaction:R-HSA-209845] CYP2R1 25-hydroxylates VD3 to 25(OH)D - Homo sapiens
input	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol] [SimpleEntity:R-ALL-8963870] VD3 [endoplasmic reticulum membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	CYP2R1 25-hydroxylates VD3 to 25(OH)D
output	[SimpleEntity:R-ALL-8963879] 25(OH)D [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-209845
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-211916] Vitamins [Pathway:R-MMU-196791] Vitamin D (calciferol) metabolism
(precedingEvent)	[Reaction:R-MMU-209868] CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D
(inferredTo)	[Reaction:R-HSA-209845] CYP2R1 25-hydroxylates VD3 to 25(OH)D