Reactome | CYP24A1 hydroxylates 1,25(OH)2D, inactivating it

Schema > Reaction > Entries

CYP24A1 hydroxylates 1,25(OH)2D, inactivating it Show undefined attributes

catalystActivity	[CatalystActivity:10006132] 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity of CYP24A1 [mitochondrial inner membrane]
category	transition
compartment	[Compartment:70616] mitochondrial inner membrane [Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10006134
displayName	CYP24A1 hydroxylates 1,25(OH)2D, inactivating it
eventOf	[Pathway:R-MMU-196791] Vitamin D (calciferol) metabolism - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-209765] CYP24A1 hydroxylates 1,25(OH)2D, inactivating it - Homo sapiens
input	[SimpleEntity:R-ALL-209800] 1,25(OH)2D [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	CYP24A1 hydroxylates 1,25(OH)2D, inactivating it
output	[SimpleEntity:R-ALL-350159] CTA [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent	[Reaction:R-MMU-209868] CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D - Mus musculus
regulatedBy	[PositiveRegulation:9692886] Positive regulation by 'Fru [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-209765
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-196791] Vitamin D (calciferol) metabolism
(inferredTo)	[Reaction:R-HSA-209765] CYP24A1 hydroxylates 1,25(OH)2D, inactivating it

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