Reactome | Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex

Schema > Reaction > Entries

Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex Show undefined attributes

catalystActivity	[CatalystActivity:10006099] ubiquitin-protein transferase activity of BTRC:CUL1:RBX1:SKP1 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10006101
displayName	Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex
eventOf	[Pathway:R-MMU-9020702] Interleukin-1 signaling - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-209063] Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex - Homo sapiens
input	[Complex:R-MMU-206891] NFKB1(1-433):RELA:p-S32,S36-NFKBIA:BTRC:CUL1:RBX1:SKP1 [cytosol] [DefinedSet:R-MMU-113595] Ub [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex NFKB1(1-433):RELA:p-S32,S36-NFKBIA:BTRC:CUL1:RBX1:SKP1 is ubiquitinated
output	[Complex:R-MMU-9012428] BTRC:CUL1:RBX1:SKP1:NFKB1:RELA:p-S32,S36-NFKBIA:Ub [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-209063
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-9020702] Interleukin-1 signaling
(inferredTo)	[Reaction:R-HSA-209063] Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex

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