Reactome | Gamma secretase cleaves Dner:Notch1 complex

Schema > BlackBoxEvent > Entries

authored	[InstanceEdit:2121208] Egan, SE, Orlic-Milacic, M, 2011-11-14
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:2067639] Orlic-Milacic, M, 2012-01-25
dbId	2067638
displayName	Gamma secretase cleaves Dner:Notch1 complex
edited	[InstanceEdit:2106576] Orlic-Milacic, M, 2012-02-10 [InstanceEdit:2098673] D'Eustachio, P, 2012-02-06
entityOnOtherCell	[EntityWithAccessionedSequence:R-MMU-2066286] Dner [plasma membrane] - Mus musculus
input	[Complex:R-MMU-2066711] Dner:Notch1:Dtx1/2/4 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1890294] DNER acts as a neuron-specific Notch ligand during Bergmann glial development
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Gamma secretase cleaves Dner:Notch1 complex
orthologousEvent	[BlackBoxEvent:R-HSA-1980112] Cleavage of DNER:NOTCH1 complex releases NICD1 - Homo sapiens
output	[Complex:R-MMU-2067634] NICD1:Dtx1/2/4 [cytosol]
regulatedBy	[PositiveRegulation:R-MMU-2067642] Positive regulation by 'gamma-secretase [plasma membrane]'
releaseDate	2012-03-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2121207] Haw, R, 2012-02-06
schemaClass	BlackBoxEvent
species	[Species:48892] Mus musculus
stId	R-MMU-2067638
summation	[Summation:2067646] In the mouse myogenic cell line C2C12, transfected with a fu...

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