Reactome | DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A

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DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A Show undefined attributes

catalystActivity	[CatalystActivity:10005631] deoxyhypusine monooxygenase activity of DOHH:Fe++ [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10005633
displayName	DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A
eventOf	[Pathway:R-MMU-204626] Hypusine synthesis from eIF5A-lysine - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-204662] DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A - Homo sapiens
input	[DefinedSet:R-MMU-3149583] Dhp-K50-EIF5A [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-73473] NADH [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A EIF5A(Dhp) + O2 => EIF5A(Hyp)
output	[SimpleEntity:R-ALL-29356] H2O [cytosol] [DefinedSet:R-MMU-204658] Hyp-K50-EIF5A [cytosol] [SimpleEntity:R-ALL-29360] NAD+ [cytosol]
precedingEvent	[Reaction:R-MMU-204647] DHPS tetramer synthesizes Dhp-K50-EIF5A from EIF5A and spermidine - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-204662
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-204626] Hypusine synthesis from eIF5A-lysine
(inferredTo)	[Reaction:R-HSA-204662] DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A

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