Reactome | Metabolism of Angiotensinogen to Angiotensins

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Metabolism of Angiotensinogen to Angiotensins Show undefined attributes

compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10100845
displayName	Metabolism of Angiotensinogen to Angiotensins
eventOf	[Pathway:R-MMU-2980736] Peptide hormone metabolism - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:172124] angiotensin maturation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-MMU-2022412] Renin hydrolyzes Angiotensinogen to AGT(25-34) (Angiotensin-(1-10)) - Mus musculus [Reaction:R-MMU-2022403] Renin:Prorenin Receptor hydrolyzes Angiotensinogen to AGT(25-34) (Angiotensin-(1-10)) - Mus musculus [Reaction:R-MMU-2065357] Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to AGT(25-35) (Angiotensin-(1-10)) - Mus musculus [Reaction:R-MMU-2022405] ACE:Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) - Mus musculus [Reaction:R-MMU-2065355] Secreted ACE:Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) - Mus musculus [Reaction:R-MMU-2022383] Chymase hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) - Mus musculus [Reaction:R-MMU-2022411] Cathepsin G hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) - Mus musculus [Reaction:R-MMU-2022381] Cathepsin Z (Cathepsin X) hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) - Mus musculus [Reaction:R-MMU-2022378] ACE2(18-805):Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-33) (Angiotensin-(1-9)) - Mus musculus [Reaction:R-MMU-2022398] ACE:Zn2+ hydrolyzes AGT(25-33) (Angiotensin-(1-9)) to AGT(25-31) (Angiotensin-(1-7)) - Mus musculus [Reaction:R-MMU-2022368] MME:Zn2+ (Neprilysin) hydrolyses AGT(25-33) (Angiotensin-(1-9)) to AGT(25-31) (Angiotensin-(1-7) - Mus musculus [Reaction:R-MMU-2022396] MME:Zn2+ (Neprilysin) hydrolyses AGT(25-34) (Angiotensin-(1-10)) to AGT(25-31) (Angiotensin-(1-7)) - Mus musculus [Reaction:R-MMU-2022399] ENPEP:Zn2+ hydrolyzes AGT(25-32) (Angiotensin-(1-8)) to AGT(26-32) (Angiotensin-(2-8)) - Mus musculus [Reaction:R-MMU-2022379] ACE2(18-805):Zn2+ hydrolyzes AGT(25-32) (Angiotensin-(1-8)) to AGT(25-31) (Angiotensin-(1-7)) - Mus musculus [Reaction:R-MMU-2028294] Mast Cell Carboxypeptidase hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-33) (Angiotensin-(1-9)) - Mus musculus [Reaction:R-MMU-9619024] CES1 trimer hydrolyses ACEI pro-drugs to ACEIs - Mus musculus [Reaction:R-MMU-9614933] ACEIs bind ACE - Mus musculus
inferredFrom	[Pathway:R-HSA-2022377] Metabolism of Angiotensinogen to Angiotensins - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Metabolism of Angiotensinogen to Angiotensins
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-2022377
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-2980736] Peptide hormone metabolism
(inferredTo)	[Pathway:R-HSA-2022377] Metabolism of Angiotensinogen to Angiotensins

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