Reactome | pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis

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pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis Show undefined attributes

catalystActivity	[CatalystActivity:10003449] AMP-activated protein kinase activity of AMPK heterotrimer (active) [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10003451
displayName	pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis
eventOf	[Pathway:R-MMU-200425] Carnitine shuttle - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:260763] fatty acid homeostasis
inferredFrom	[Reaction:R-HSA-200423] pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Polymer:R-MMU-8867341] Btn-ACACB:2Mn2+ polymer [mitochondrial outer membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis ATP + L-seryl-(protein) => ADP + H(+) + O-phospho-L-seryl-(protein)
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Polymer:R-MMU-8876893] Btn-p-S222-ACACB:2Mn2+ polymer [mitochondrial outer membrane] [SimpleEntity:R-ALL-70106] H+ [cytosol]
precedingEvent	[Reaction:R-MMU-200421] Activation of cytosolic AMPK by phosphorylation - Mus musculus [Reaction:R-MMU-380930] Phosphorylated AMPK binds AMP - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-200423
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-200425] Carnitine shuttle
(inferredTo)	[Reaction:R-HSA-200423] pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis

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