Reactome | Active IRS recruits PI3K to the plasma membrane and activates it

Schema > Reaction > Entries

Active IRS recruits PI3K to the plasma membrane and activates it Show undefined attributes

category	binding
compartment	[Compartment:947587] cytoplasmic side of plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10002388
displayName	Active IRS recruits PI3K to the plasma membrane and activates it
eventOf	[Pathway:R-MMU-198203] PI3K/AKT activation - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-MMU-198266] PI3K produces PIP3 and other phosphatidyl inositides - Mus musculus [Reaction:R-MMU-2316434] PI3K phosphorylates PIP2 to PIP3 - Mus musculus
inferredFrom	[Reaction:R-HSA-198315] Active IRS recruits PI3K to the plasma membrane and activates it - Homo sapiens
input	[Complex:R-MMU-198299] Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] [Complex:R-MMU-74693] PI3K [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Active IRS recruits PI3K to the plasma membrane and activates it
output	[Complex:R-MMU-213135] Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-198315
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-198203] PI3K/AKT activation
(precedingEvent)	[Reaction:R-MMU-2316434] PI3K phosphorylates PIP2 to PIP3 [BlackBoxEvent:R-MMU-198266] PI3K produces PIP3 and other phosphatidyl inositides
(inferredTo)	[Reaction:R-HSA-198315] Active IRS recruits PI3K to the plasma membrane and activates it

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