Reactome | 4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol

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4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol Show undefined attributes

catalystActivity	[CatalystActivity:10001995] 3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity of HSD17B7 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10002029
displayName	4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol
eventOf	[Pathway:R-MMU-6807047] Cholesterol biosynthesis via desmosterol (Bloch pathway) - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-194669] 4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol - Mus musculus
inferredFrom	[Reaction:R-HSA-194689] 4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol - Homo sapiens
input	[SimpleEntity:R-ALL-194667] dh4MZYMOL [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol 4alpha-methylzymosterol + NADP(+) => 3-dehydro-4alpha-methylzymosterol + NADPH + H(+)
output	[SimpleEntity:R-ALL-194723] 4MZYMOL [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent	[Reaction:R-MMU-194642] 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-194689
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-6807047] Cholesterol biosynthesis via desmosterol (Bloch pathway)
(precedingEvent)	[Reaction:R-MMU-194669] 4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol
(inferredTo)	[Reaction:R-HSA-194689] 4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol

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