Reactome | CYP17A1 cleaves 17aHPREG to DHA

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CYP17A1 cleaves 17aHPREG to DHA Show undefined attributes

catalystActivity	[CatalystActivity:10001527] steroid 17-alpha-monooxygenase activity of CYP17A1 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10001531
displayName	CYP17A1 cleaves 17aHPREG to DHA
eventOf	[Pathway:R-MMU-193048] Androgen biosynthesis - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-193073] HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST - Mus musculus
inferredFrom	[Reaction:R-HSA-193070] CYP17A1 cleaves 17aHPREG to DHA - Homo sapiens
input	[SimpleEntity:R-ALL-193124] 17aHPREG [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	CYP17A1 cleaves 17aHPREG to DHA Side chain cleavage of 17alpha-hydroxypregnenolone to yield DHA 17alpha-hydroxyprenenolone + NADPH + H+ + O2 => DHA (dehydroepiandrostenedione) + NADP+ + H2O + acetaldehyde
output	[SimpleEntity:R-ALL-29510] CH3CHO [cytosol] [SimpleEntity:R-ALL-176626] DHEA [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent	[Reaction:R-MMU-193068] CYP17A1 17-hydroxylates PREG - Mus musculus
regulatedBy	[PositiveRegulation:10001520] Positive regulation by 'POMC(138-176) [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-193070
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-193048] Androgen biosynthesis
(precedingEvent)	[Reaction:R-MMU-193073] HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST
(inferredTo)	[Reaction:R-HSA-193070] CYP17A1 cleaves 17aHPREG to DHA

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