Reactome | MafA-, NKX2-2-, PAX6-, and PDX1-dependent synthesis of insulin precursor protein

Schema > BlackBoxEvent > Entries

MafA-, NKX2-2-, PAX6-, and PDX1-dependent synthesis of insulin precursor protein Show undefined attributes

authored	[InstanceEdit:351500] Ferrer, J, Tello-Ruiz, MK, 2008-05-23
category	omitted
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:186665] Tello-Ruiz, MK, 2006-08-14 15:25:20
dbId	186535
deleted	[Deleted:8863058] Deletion of instance: 186710 [Deleted:8863059] Deletion of instance: 186468 [Deleted:8863060] Deletion of instance: 186479
displayName	MafA-, NKX2-2-, PAX6-, and PDX1-dependent synthesis of insulin precursor protein
edited	[InstanceEdit:190295] Tello-Ruiz, MK, 2006-12-19 19:02:30
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:187350] Members of the large Maf transcription family regulate insulin gene transcription in islet beta cells [LiteratureReference:187371] Identification of beta-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA [LiteratureReference:189541] MafA is a glucose-regulated and pancreatic beta-cell-specific transcriptional activator for the insulin gene [LiteratureReference:187478] Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells. [LiteratureReference:187269] Transcription factor occupancy of the insulin gene in vivo. Evidence for direct regulation by Nkx2.2. [LiteratureReference:187476] Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development [LiteratureReference:189588] Pax6 is required for differentiation of glucagon-producing alpha-cells in mouse pancreas [LiteratureReference:186720] Quantitative assessment of gene targeting in vitro and in vivo by the pancreatic transcription factor, Pdx1. Importance of chromatin structure in directing promoter binding. [LiteratureReference:186688] IPF1, a homeodomain-containing transactivator of the insulin gene [LiteratureReference:186519] beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	MafA-, NKX2-2-, PAX6-, and PDX1-dependent synthesis of insulin precursor protein
orthologousEvent	[BlackBoxEvent:R-HSA-211289] MAFA-, NKX2-2-, PAX6-, and PDX1-dependent synthesis of insulin precursor protein - Homo sapiens
output	[EntityWithAccessionedSequence:R-MMU-189777] Ins1 [cytosol]
regulatedBy	[PositiveRegulation:R-MMU-189707] Positive regulation by 'MafA [nucleoplasm]' [PositiveRegulation:R-MMU-189712] Positive regulation by 'ipf1/pdx1 [nucleoplasm]' [PositiveRegulation:R-MMU-189739] Positive regulation by 'nkx2.2 [nucleoplasm]' [PositiveRegulation:R-MMU-189791] Positive regulation by 'Pax6 [nucleoplasm]'
releaseDate	2008-06-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:349683] Jensen, J, 2008-05-12 21:46:53
schemaClass	BlackBoxEvent
species	[Species:48892] Mus musculus
stId	R-MMU-186535
summation	[Summation:187348] Human and mouse MafA/RIPE3b1 bind to the insulin promoter in...
updateTrackers	[UpdateTracker:9783208] Update Tracker - [BlackBoxEvent:186535] MafA-, NKX2-2-, PAX6-, and PDX1-dependent synthesis of insulin precursor protein - v57:[addLiteratureReference, addRegulator, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9783208] Update Tracker - [BlackBoxEvent:186535] MafA-, NKX2-2-, PAX6-, and PDX1-dependent synthesis of insulin precursor protein - v57:[addLiteratureReference, addRegulator, modifyText]
(replacementInstances)	[Deleted:8863058] Deletion of instance: 186710 [Deleted:8863059] Deletion of instance: 186468 [Deleted:8863060] Deletion of instance: 186479

Cite Us!