Reactome | I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol

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I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol Show undefined attributes

catalystActivity	[CatalystActivity:10036712] inositol-1,3,4-trisphosphate 4-phosphatase activity of INPP4A/B [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10036714
displayName	I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol
eventOf	[Pathway:R-MMU-1855183] Synthesis of IP2, IP, and Ins in the cytosol - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-1855180] I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-994123] I(1,3,4)P3 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol
output	[SimpleEntity:R-ALL-1629769] I(1,3)P2 [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-MMU-1855218] I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol - Mus musculus [Reaction:R-MMU-1855213] I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane - Mus musculus [Reaction:R-MMU-1855171] I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-1855180
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-1855183] Synthesis of IP2, IP, and Ins in the cytosol
(inferredTo)	[Reaction:R-HSA-1855180] I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol

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