Reactome | Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1

Schema > Reaction > Entries

Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 Show undefined attributes

category	dissociation
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	9998701
displayName	Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1
eventOf	[Pathway:R-MMU-176409] APC/C:Cdc20 mediated degradation of mitotic proteins - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-174120] Association of Cyclin B:Cdc2 with Cdc20:APC/C complex - Mus musculus [Reaction:R-MMU-174121] Association of Securin with Cdc20:APC/C complex - Mus musculus [Reaction:R-MMU-174224] Dissociation of Cdc20 from APC/C complex - Mus musculus
goBiologicalProcess	[GO_BiologicalProcess:3446115] regulation of mitotic cell cycle phase transition
inferredFrom	[Reaction:R-HSA-174238] Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 - Homo sapiens
input	[Complex:R-MMU-141410] MCC:APC/C complex [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1
output	[Complex:R-MMU-174081] CDC20:p-APC/C [cytosol] [Complex:R-MMU-174196] hBUBR1:hBUB3:MAD2* complex [cytosol]
precedingEvent	[Reaction:R-MMU-141423] Binding of the MCC complex to the APC/C complex - Mus musculus [BlackBoxEvent:R-MMU-174255] Degradation multiubiquitinated Cyclin A - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-174238
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-176409] APC/C:Cdc20 mediated degradation of mitotic proteins
(precedingEvent)	[Reaction:R-MMU-174224] Dissociation of Cdc20 from APC/C complex [Reaction:R-MMU-174120] Association of Cyclin B:Cdc2 with Cdc20:APC/C complex [Reaction:R-MMU-174121] Association of Securin with Cdc20:APC/C complex
(inferredTo)	[Reaction:R-HSA-174238] Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1

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