Reactome | K63-linked ubiquitination of RIP1 bound to the activated TLR complex

Schema > Reaction > Entries

K63-linked ubiquitination of RIP1 bound to the activated TLR complex Show undefined attributes

catalystActivity	[CatalystActivity:9997052] ubiquitin-protein transferase activity of RIP1 ubiqutin ligases [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:74700] endosome membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	9997054
displayName	K63-linked ubiquitination of RIP1 bound to the activated TLR complex
eventOf	[Pathway:R-MMU-937041] IKK complex recruitment mediated by RIP1 - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-937029] IKBKG subunit of IKK complex binds polyubiquinated RIP1 - Mus musculus
inferredFrom	[Reaction:R-HSA-168915] K63-linked ubiquitination of RIP1 bound to the activated TLR complex - Homo sapiens
input	2 × [Polymer:R-MMU-450152] K63polyUb [cytosol] [Complex:R-MMU-168912] RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	K63-linked ubiquitination of RIP1 bound to the activated TLR complex
output	[Complex:R-MMU-937016] K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane]
precedingEvent	[Reaction:R-MMU-168921] TRIF:activated TLR3/TLR4 complex recruits RIP1 - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-168915
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-937041] IKK complex recruitment mediated by RIP1
(precedingEvent)	[Reaction:R-MMU-937029] IKBKG subunit of IKK complex binds polyubiquinated RIP1
(inferredTo)	[Reaction:R-HSA-168915] K63-linked ubiquitination of RIP1 bound to the activated TLR complex

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