Reactome | FMO1:FAD oxidizes HTAU to TAU

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FMO1:FAD oxidizes HTAU to TAU Show undefined attributes

catalystActivity	[CatalystActivity:10035648] hypotaurine monooxygenase activity of FMO1:FAD [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10035650
displayName	FMO1:FAD oxidizes HTAU to TAU
eventOf	[Pathway:R-MMU-1614558] Degradation of cysteine and homocysteine - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-1655453] FMO1:FAD oxidizes HTAU to TAU - Homo sapiens
input	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-1655445] HTAU [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	FMO1:FAD oxidizes HTAU to TAU H(+) + hypotaurine + NADPH + O2 = H2O + NADP(+) + taurine Oxidation of hypotaurine to taurine
output	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol] [SimpleEntity:R-ALL-159420] TAU [cytosol]
precedingEvent	[Reaction:R-MMU-6814153] ADO oxidises 2AET to HTAU - Mus musculus [Reaction:R-MMU-6814165] PXLP-K333-GADL1 decarboxylates CSA to HTAU - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-1655453
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-1614558] Degradation of cysteine and homocysteine
(inferredTo)	[Reaction:R-HSA-1655453] FMO1:FAD oxidizes HTAU to TAU

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