Reactome | GALNS oligomer hydrolyses sulfate from Gal6S in keratan sulfate

Schema > Reaction > Entries

GALNS oligomer hydrolyses sulfate from Gal6S in keratan sulfate Show undefined attributes

catalystActivity	[CatalystActivity:10035399] N-acetylgalactosamine-6-sulfatase activity of GALNS dimer [lysosomal lumen]
category	transition
compartment	[Compartment:161320] lysosomal lumen
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10035401
displayName	GALNS oligomer hydrolyses sulfate from Gal6S in keratan sulfate
eventOf	[Pathway:R-MMU-2022857] Keratan sulfate degradation - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-1630306] GLB1 hydrolyses a glycosaminoglycan - Mus musculus
inferredFrom	[Reaction:R-HSA-1630304] GALNS oligomer hydrolyses sulfate from Gal6S in keratan sulfate - Homo sapiens
input	[SimpleEntity:R-ALL-2105007] Gal(S)-GlcNAc(S)-Gal-GlcNAc(S)-Gal [lysosomal lumen] [SimpleEntity:R-ALL-1605715] H2O [lysosomal lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	GALNS oligomer hydrolyses sulfate from Gal6S in keratan sulfate
output	[SimpleEntity:R-ALL-2104997] Gal-GlcNAc(S)-Gal-GlcNAc(S)-Gal [lysosomal lumen] [SimpleEntity:R-ALL-1606845] SO4(2-) [lysosomal lumen]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-1630304
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-2022857] Keratan sulfate degradation
(precedingEvent)	[Reaction:R-MMU-1630306] GLB1 hydrolyses a glycosaminoglycan
(inferredTo)	[Reaction:R-HSA-1630304] GALNS oligomer hydrolyses sulfate from Gal6S in keratan sulfate

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