Reactome | crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin

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crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin Show undefined attributes

catalystActivity	[CatalystActivity:9994867] serine-type endopeptidase activity of fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen [extracellular region]
category	transition
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	9994869
displayName	crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin
eventOf	[Pathway:R-MMU-75205] Dissolution of Fibrin Clot - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-158893] alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin - Mus musculus [Reaction:R-MMU-158766] fibrin multimer, crosslinked -> fibrin digestion products (plasmin) - Mus musculus
inferredFrom	[Reaction:R-HSA-158744] crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin - Homo sapiens
input	[Complex:R-MMU-158786] fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin
output	[Complex:R-MMU-158745] fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) [extracellular region] [Complex:R-MMU-158770] Plasmin [extracellular region]
precedingEvent	[Reaction:R-MMU-158756] crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-158744
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-75205] Dissolution of Fibrin Clot
(precedingEvent)	[Reaction:R-MMU-158893] alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin [Reaction:R-MMU-158766] fibrin multimer, crosslinked -> fibrin digestion products (plasmin)
(inferredTo)	[Reaction:R-HSA-158744] crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin

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