Reactome | p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane]

Schema > Complex > Entries

catalystActivities	[CatalystActivity:10004178] nitric-oxide synthase activity of p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] [CatalystActivity:10033677] tetrahydrobiopterin binding activity of p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane]
compartment	[Compartment:876] plasma membrane
consumedByEvent	[Reaction:R-MMU-1497796] BH2 binding can lead to eNOS uncoupling - Mus musculus
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10004177
displayName	p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane]
hasComponent	[SimpleEntity:R-ALL-29870] BH4 [cytosol] [Complex:R-MMU-202121] p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane]
inDisease	false
inferredFrom	[Complex:R-HSA-1497830] p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] - Homo sapiens
maxDepth	4
name	p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4
producedByEvent	[Reaction:R-MMU-1497784] The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle - Mus musculus
schemaClass	Complex
species	[Species:48892] Mus musculus
stId	R-MMU-1497830
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(physicalEntity)	[CatalystActivity:10004178] nitric-oxide synthase activity of p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] [CatalystActivity:10033677] tetrahydrobiopterin binding activity of p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane]
(output)	[Reaction:R-MMU-1497784] The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle
(input)	[Reaction:R-MMU-1497796] BH2 binding can lead to eNOS uncoupling
(inferredTo)	[Complex:R-HSA-1497830] p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane]