Reactome | PE is hydrolyzed to 2-acyl LPE by PLA2G4C

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PE is hydrolyzed to 2-acyl LPE by PLA2G4C Show undefined attributes

catalystActivity	[CatalystActivity:10033399] glycerophospholipid phospholipase A1 activity of PLA2G4C [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10033452
displayName	PE is hydrolyzed to 2-acyl LPE by PLA2G4C
eventOf	[Pathway:R-MMU-1482839] Acyl chain remodelling of PE - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-1482545] 2-acyl LPE is hydrolyzed to GPETA by PLA2G4C - Mus musculus [Reaction:R-MMU-1482646] 2-acyl LPE is acylated to PE by LPEAT - Mus musculus
inferredFrom	[Reaction:R-HSA-1482892] PE is hydrolyzed to 2-acyl LPE by PLA2G4C - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-1500581] PE [endoplasmic reticulum membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	PE is hydrolyzed to 2-acyl LPE by PLA2G4C
output	[SimpleEntity:R-ALL-1498729] 2-acyl LPE [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-1524021] LCFA(-) [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-MMU-1482667] 1-acyl LPE is acylated to PE by LPEAT - Mus musculus [Reaction:R-MMU-1482646] 2-acyl LPE is acylated to PE by LPEAT - Mus musculus [Reaction:R-MMU-1482962] CDP-ETA and DAG are converted to PE by CEPT1/EPT1 - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-1482892
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-1482839] Acyl chain remodelling of PE
(precedingEvent)	[Reaction:R-MMU-1482545] 2-acyl LPE is hydrolyzed to GPETA by PLA2G4C [Reaction:R-MMU-1482646] 2-acyl LPE is acylated to PE by LPEAT
(inferredTo)	[Reaction:R-HSA-1482892] PE is hydrolyzed to 2-acyl LPE by PLA2G4C