Reactome | Fusion of Glut4 Vesicle with the Plasma Membrane

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Fusion of Glut4 Vesicle with the Plasma Membrane Show undefined attributes

authored	[InstanceEdit:1445151] May, B, 2011-07-12
category	omitted
compartment	[Compartment:876] plasma membrane [Compartment:437051] cytoplasmic vesicle membrane
created	[InstanceEdit:1449564] May, B, 2011-07-15
dbId	1449573
displayName	Fusion of Glut4 Vesicle with the Plasma Membrane
edited	[InstanceEdit:1445151] May, B, 2011-07-12
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-MMU-1449603] Glut4:Tug [cytoplasmic vesicle membrane] [EntityWithAccessionedSequence:R-MMU-1449569] Snap23 [plasma membrane] [Complex:R-MMU-2263481] Stx4:Munc18c [plasma membrane] [EntityWithAccessionedSequence:R-MMU-1449609] Vamp2 [cytoplasmic vesicle membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1449611] Role of SNAP23 in insulin-induced translocation of GLUT4 in 3T3-L1 adipocytes. Mediation of complex formation between syntaxin4 and VAMP2 [LiteratureReference:1449592] Myosin 5a is an insulin-stimulated Akt2 (protein kinase Bbeta) substrate modulating GLUT4 vesicle translocation [LiteratureReference:1449568] CaMKII-mediated phosphorylation of the myosin motor Myo1c is required for insulin-stimulated GLUT4 translocation in adipocytes [LiteratureReference:1458464] Myo1c regulates glucose uptake in mouse skeletal muscle [LiteratureReference:1458469] Unconventional myosin Myo1c promotes membrane fusion in a regulated exocytic pathway [LiteratureReference:2262703] A transgenic mouse model to study glucose transporter 4myc regulation in skeletal muscle [LiteratureReference:1449586] Functional cloning of TUG as a regulator of GLUT4 glucose transporter trafficking [LiteratureReference:1449636] The glucose transporter 4-regulating protein TUG is essential for highly insulin-responsive glucose uptake in 3T3-L1 adipocytes [LiteratureReference:2263459] Munc18c phosphorylation by the insulin receptor links cell signaling directly to SNARE exocytosis
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Fusion of Glut4 Vesicle with the Plasma Membrane
orthologousEvent	[BlackBoxEvent:R-HSA-1449574] SLC2A4 (GLUT4) vesicle fuses with the plasma membrane - Homo sapiens
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-MMU-1449571] Aspscr1 [cytoplasmic vesicle membrane] [EntityWithAccessionedSequence:R-MMU-2263478] p-Y521-Stxbp3 (Munc18c) [plasma membrane] [EntityWithAccessionedSequence:R-MMU-1449578] Slc2a4 [plasma membrane] [Complex:R-MMU-1449562] Vamp2:Stx4:Snap23 [plasma membrane]
precedingEvent	[BlackBoxEvent:R-MMU-2316351] Translocation of Glut4 Vesicle and Docking at the Plasma Membrane - Mus musculus
releaseDate	2012-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2454132] Klip, Amira, 2012-08-21
schemaClass	BlackBoxEvent
species	[Species:48892] Mus musculus
stId	R-MMU-1449573
summation	[Summation:1458644] After docking at the membrane Vamp2 on the vesicle interacts...

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