Reactome | Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components

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Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Show undefined attributes

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10099113
displayName	Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
eventOf	[Pathway:R-MMU-69618] Mitotic Spindle Checkpoint - Mus musculus [Pathway:R-MMU-176408] Regulation of APC/C activators between G1/S and early anaphase - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-MMU-141429] Inactivation of APC/C via CDC20 sequestration - Mus musculus [Pathway:R-MMU-141430] Inactivation of APC/C via direct inhibition of the APC/C complex - Mus musculus
inferredFrom	[Pathway:R-HSA-141405] Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
precedingEvent	[Pathway:R-MMU-141424] Amplification of signal from the kinetochores - Mus musculus
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-141405
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-176408] Regulation of APC/C activators between G1/S and early anaphase [Pathway:R-MMU-69618] Mitotic Spindle Checkpoint
(inferredTo)	[Pathway:R-HSA-141405] Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components

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