Reactome | SPRY2 binds CBL

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SPRY2 binds CBL Show undefined attributes

category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10029818
displayName	SPRY2 binds CBL
eventOf	[Pathway:R-MMU-1295596] Spry regulation of FGF signaling - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-934604] Phosphorylated SPRY2 is ubiquitinated by CBL - Mus musculus
inferredFrom	[Reaction:R-HSA-1295622] SPRY2 binds CBL - Homo sapiens
input	[EntityWithAccessionedSequence:R-MMU-112199] CBL [cytosol] [Complex:R-MMU-934598] PP2A(A:C):Y55/Y227-pSPRY2 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	SPRY2 binds CBL
output	[Complex:R-MMU-934544] PP2A (A:C) [cytosol] [Complex:R-MMU-934576] Y55/Y227-pSPRY2:CBL [plasma membrane]
precedingEvent	[Reaction:R-MMU-1295609] SRC phosphorylates SPRY2 on Y55 and Y227 - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-1295622
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-1295596] Spry regulation of FGF signaling
(precedingEvent)	[Reaction:R-MMU-934604] Phosphorylated SPRY2 is ubiquitinated by CBL
(inferredTo)	[Reaction:R-HSA-1295622] SPRY2 binds CBL