Reactome | The Nodal Receptor binds Nodal ligands

Schema > Reaction > Entries

The Nodal Receptor binds Nodal ligands Show undefined attributes

authored	[InstanceEdit:1225902] May, B, 2011-02-13
category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:1225868] May, B, 2011-03-03
dbId	1225898
displayName	The Nodal Receptor binds Nodal ligands
edited	[InstanceEdit:1225902] May, B, 2011-02-13
input	[DefinedSet:R-MMU-1226028] Nodal dimer, Nodal:Gdf1 [extracellular region] [DefinedSet:R-MMU-1225880] Nodal Receptor [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1181296] ALK7, a receptor for nodal, is dispensable for embryogenesis and left-right patterning in the mouse [LiteratureReference:1181094] The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development [LiteratureReference:1181314] Nodal signals to Smads through Cripto-dependent and Cripto-independent mechanisms [LiteratureReference:1225867] Cripto is a noncompetitive activin antagonist that forms analogous signaling complexes with activin and nodal [LiteratureReference:1226026] Long-range action of Nodal requires interaction with GDF1 [LiteratureReference:6788941] Nodal�Gdf1 heterodimers with bound prodomains enable serum-independent nodal signaling and endoderm differentiation
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	The Nodal Receptor binds Nodal ligands
orthologousEvent	[Reaction:R-HSA-1181155] The NODAL Receptor binds NODAL ligands - Homo sapiens
output	[Complex:R-MMU-1225888] Nodal:Nodal Receptor [plasma membrane]
precedingEvent	[Reaction:R-MMU-1181148] Cleavage of Nodal proprotein - Mus musculus
releaseDate	2011-09-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1529118] Peng, C, 2011-08-24
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-1225898
summation	[Summation:1225986] Nodal homodimers and Nodal:Gdf1 heterodimers bind Activin/No...
updateTrackers	[UpdateTracker:9784165] Update Tracker - [Reaction:1225898] The Nodal Receptor binds Nodal ligands - v54:[addLiteratureReference]

Referrals

(updatedInstance)

[UpdateTracker:9784165] Update Tracker - [Reaction:1225898] The Nodal Receptor binds Nodal ligands - v54:[addLiteratureReference]