Reactome | IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane]

Schema > Complex > Entries

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	9991668
displayName	IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane]
hasComponent	[EntityWithAccessionedSequence:R-MMU-162573] phospho-p-Y542,Y580-PTPN11 [cytosol] [Complex:R-MMU-1112594] Tyrosine phosphorylated IL6 receptor hexamer:Activated JAKs [plasma membrane]
inDisease	false
inferredFrom	[Complex:R-HSA-1112753] IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] - Homo sapiens
maxDepth	7
name	IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11
positivelyRegulates	[PositiveRegulation:9991671] Positive regulation by 'IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane]'
producedByEvent	[Reaction:R-MMU-1112703] PTPN11 is phosphorylated - Mus musculus
schemaClass	Complex
species	[Species:48892] Mus musculus
stId	R-MMU-1112753
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(output)	[Reaction:R-MMU-1112703] PTPN11 is phosphorylated
(regulator)	[PositiveRegulation:9991671] Positive regulation by 'IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane]'
(inferredTo)	[Complex:R-HSA-1112753] IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane]

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