Reactome | POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template

Schema > Reaction > Entries

POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template Show undefined attributes

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	9992015
displayName	POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template
eventOf	[Pathway:R-MMU-110320] Translesion Synthesis by POLH - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-110317] Insertion of correct bases opposite the lesion by POLH - Mus musculus
inferredFrom	[Reaction:R-HSA-110316] POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template - Homo sapiens
input	[Complex:R-MMU-5653905] MonoUb:K164-PCNA:RPA:RFC:TT-CPD-DNA Template [nucleoplasm] [EntityWithAccessionedSequence:R-MMU-110287] POLH [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template Binding of Pol eta to lesioned DNA template
output	[Complex:R-MMU-110288] POLH:MonoUb:K164-PCNA:RPA:RFC:TT-CPD-DNA Template [nucleoplasm]
precedingEvent	[Reaction:R-MMU-5652009] RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA - Mus musculus
regulatedBy	[NegativeRegulation:9992016] Negative regulation by 'RCHY1 [nucleoplasm]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-110316
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-110320] Translesion Synthesis by POLH
(precedingEvent)	[Reaction:R-MMU-110317] Insertion of correct bases opposite the lesion by POLH
(inferredTo)	[Reaction:R-HSA-110316] POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template

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