Reactome | MAP2K1 binds MAPK3

Schema > Reaction > Entries

MAP2K1 binds MAPK3 Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	9991670
displayName	MAP2K1 binds MAPK3
eventOf	[Pathway:R-MMU-110056] MAPK3 (ERK1) activation - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-109860] MAP2K1 phosphorylates MAPK3 - Mus musculus
inferredFrom	[Reaction:R-HSA-109857] MAP2K1 binds MAPK3 - Homo sapiens
input	[EntityWithAccessionedSequence:R-MMU-59284] MAPK3 [cytosol] [EntityWithAccessionedSequence:R-MMU-451693] Phospho Mek1 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	MAP2K1 binds MAPK3
output	[Complex:R-MMU-109838] p-2S-MAP2K1:MAPK3 [cytosol]
regulatedBy	[PositiveRegulation:9991671] Positive regulation by 'IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-109857
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-110056] MAPK3 (ERK1) activation
(precedingEvent)	[Reaction:R-MMU-109860] MAP2K1 phosphorylates MAPK3
(inferredTo)	[Reaction:R-HSA-109857] MAP2K1 binds MAPK3