Reactome | IL6 binds IL6R

Schema > Reaction > Entries

IL6 binds IL6R Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10028330
displayName	IL6 binds IL6R
eventOf	[Pathway:R-MMU-1059683] Interleukin-6 signaling - Mus musculus [Pathway:R-MMU-9958825] Activation of STAT3 by cadherin engagement - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-1067688] IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2) - Mus musculus
inferredFrom	[Reaction:R-HSA-1067667] IL6 binds IL6R - Homo sapiens
input	[EntityWithAccessionedSequence:R-MMU-447100] Il6 [extracellular region] [EntityWithAccessionedSequence:R-MMU-197824] Il6ra [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	IL6 binds IL6R Interleukin-6 binds to IL-6 receptor alpha subunit
output	[Complex:R-MMU-1067638] IL6:IL6R [plasma membrane]
regulatedBy	[NegativeRegulation:10028331] Negative regulation by 'IL6R:IL6R inhibitors [plasma membrane]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-1067667
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-9958825] Activation of STAT3 by cadherin engagement [Pathway:R-MMU-1059683] Interleukin-6 signaling
(precedingEvent)	[Reaction:R-MMU-1067688] IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2)
(inferredTo)	[Reaction:R-HSA-1067667] IL6 binds IL6R