Reactome | Recruitment of other CPA components to pre-mRNA-bound CPA core

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Recruitment of other CPA components to pre-mRNA-bound CPA core Show undefined attributes

authored	[InstanceEdit:72178] Wahle, E, 2003-06-05 08:30:31 [InstanceEdit:9770563] Ahluwalia, Rhea, 2025-10-01
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9970177] Orlic-Milacic, Marija, 2025-10-29
dbId	9970179
deleted	[Deleted:9971718] Deletion of instance: 72231
displayName	Recruitment of other CPA components to pre-mRNA-bound CPA core
edited	[InstanceEdit:9971425] Orlic-Milacic, Marija, 2025-11-06
eventOf	[Pathway:R-HSA-9770562] mRNA Polyadenylation - Homo sapiens
followingEvent	[Reaction:R-HSA-9970190] PP1 dephosphorylates RNA Pol II - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-HSA-72020] CF II [nucleoplasm] [Complex:R-HSA-9970140] Core CPA complex:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] [DefinedSet:R-HSA-9970174] PAPOLA, PAPOLG, TUT1 [nucleoplasm] [Complex:R-HSA-9970180] PP1:PPP1R10 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9970176] RBBP6 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8938798] Molecular architecture of the human pre-mRNA 3' processing complex [LiteratureReference:9970236] Overlapping and distinct functions of SPT6, PNUTS, and PCF11 in regulating transcription termination [LiteratureReference:9770688] Reconstitution of mammalian cleavage factor II involved in 3' processing of mRNA precursors [LiteratureReference:9970244] Reconstitution of 3' end processing of mammalian pre-mRNA reveals a central role of RBBP6 [LiteratureReference:9970546] RBBP6 isoforms regulate the human polyadenylation machinery and modulate expression of mRNAs with AU-rich 3' UTRs [LiteratureReference:9970561] RBBP6 activates the pre-mRNA 3' end processing machinery in humans [LiteratureReference:9970841] A PtdIns4,5P2-regulated nuclear poly(A) polymerase controls expression of select mRNAs [LiteratureReference:9970840] Star-PAP control of BIK expression and apoptosis is regulated by nuclear PIPKI? and PKC? signaling [LiteratureReference:9970843] Crystal structure of human poly(A) polymerase gamma reveals a conserved catalytic core for canonical poly(A) polymerases [LiteratureReference:9970842] Distinct regulation of alternative polyadenylation and gene expression by nuclear poly(A) polymerases
maxDepth	1
modified	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
name	Recruitment of other CPA components to pre-mRNA-bound CPA core
negativePrecedingEvent	[NegativePrecedingEvent:9971460] Futile Cycle: CPA complex components dissociate from polyadenylated pre-mRNA (distal 3'UTR PAS) [NegativePrecedingEvent:9971459] Futile Cycle: CPA complex components dissociate from polyadenylated pre-mRNA (intronic PAS) [NegativePrecedingEvent:9971464] Futile Cycle: CPA complex components dissociate from polyadenylated pre-mRNA (proximal 3'UTR PAS)
orthologousEvent	[Reaction:R-BTA-9970179] Recruitment of other CPA components to pre-mRNA-bound CPA core - Bos taurus [Reaction:R-CFA-9970179] Recruitment of other CPA components to pre-mRNA-bound CPA core - Canis familiaris [Reaction:R-RNO-9970179] Recruitment of other CPA components to pre-mRNA-bound CPA core - Rattus norvegicus [Reaction:R-MMU-9970179] Recruitment of other CPA components to pre-mRNA-bound CPA core - Mus musculus
output	[Complex:R-HSA-9970178] CPA:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm]
precedingEvent	[Reaction:R-HSA-9970141] Core CPA complex binds capped pre-mRNA - Homo sapiens [Reaction:R-HSA-9770564] Formation of the CF II complex - Homo sapiens
releaseDate	2025-12-08
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9971220] Ahluwalia, Rhea, 2025-11-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9970179
summation	[Summation:9970213] Components of the cleavage and polyadenylation (CPA) comp...

Referrals

(replacementInstances)	[Deleted:9971718] Deletion of instance: 72231
(hasEvent)	[Pathway:R-HSA-9770562] mRNA Polyadenylation
(precedingEvent)	[Reaction:R-HSA-9970190] PP1 dephosphorylates RNA Pol II

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