Reactome | TP53 binds CPS1 gene

Schema > Reaction > Entries

authored	[InstanceEdit:9959888] Rothfels, Karen, 2025-07-02
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9959861] Rothfels, Karen, 2025-07-02
dbId	9959860
displayName	TP53 binds CPS1 gene
edited	[InstanceEdit:9959888] Rothfels, Karen, 2025-07-02
eventOf	[Pathway:R-HSA-70635] Urea cycle - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9959874] CPS1 gene expression - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-9959836] CPS1 gene [nucleoplasm] [Complex:R-HSA-3209194] TP53 Tetramer [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9959848] p53 regulation of ammonia metabolism through urea cycle controls polyamine biosynthesis [LiteratureReference:9959828] Polyamines in cancer: integrating organismal metabolism and antitumour immunity
maxDepth	1
modified	[InstanceEdit:9970980] Rothfels, Karen, 2025-11-03
name	TP53 binds CPS1 gene
output	[Complex:R-HSA-9959843] TP53 tetramer:CPS1 gene [nucleoplasm]
releaseDate	2025-12-08
reviewStatus	[ReviewStatus:9821383] three stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9959860
summation	[Summation:9959859] TP53 binds to the CPS1 genomic region to repress transcripti...

(precedingEvent)	[BlackBoxEvent:R-HSA-9959874] CPS1 gene expression
(hasEvent)	[Pathway:R-HSA-70635] Urea cycle

Cite Us!