Reactome | RQT complex [cytosol]

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RQT complex [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-9948295] RQT complex:K63polyUb-80S Ribosome:no-go mRNA:peptidyl tRNA with nascent peptide [cytosol] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-9948291] RQT complex binds K63polyUb-80S ribosome:no-go mRNA:peptidyl-tRNA with nascent peptide - Homo sapiens
created	[InstanceEdit:9948292] May, Bruce, 2025-05-19
dbId	9948297
displayName	RQT complex [cytosol]
hasComponent	[EntityWithAccessionedSequence:R-HSA-9948320] ASCC2 [cytosol] [EntityWithAccessionedSequence:R-HSA-9948315] ASCC3 [cytosol] [EntityWithAccessionedSequence:R-HSA-9948302] TRIP4 [cytosol]
inDisease	false
inferredTo	[Complex:R-MMU-9948297] RQT complex [cytosol] - Mus musculus [Complex:R-RNO-9948297] RQT complex [cytosol] - Rattus norvegicus [Complex:R-CFA-9948297] RQT complex [cytosol] - Canis familiaris [Complex:R-BTA-9948297] RQT complex [cytosol] - Bos taurus [Complex:R-SSC-9948297] RQT complex [cytosol] - Sus scrofa [Complex:R-DRE-9948297] RQT complex [cytosol] - Danio rerio [Complex:R-XTR-9948297] RQT complex [cytosol] - Xenopus tropicalis [Complex:R-GGA-9948297] RQT complex [cytosol] - Gallus gallus [Complex:R-DME-9948297] RQT complex [cytosol] - Drosophila melanogaster [Complex:R-CEL-9948297] RQT complex [cytosol] - Caenorhabditis elegans [Complex:R-DDI-9948297] RQT complex [cytosol] - Dictyostelium discoideum [Complex:R-SPO-9948297] RQT complex [cytosol] - Schizosaccharomyces pombe [Complex:R-SCE-9948297] RQT complex [cytosol] - Saccharomyces cerevisiae [Complex:R-PFA-9948297] RQT complex [cytosol] - Plasmodium falciparum
isChimeric	false
literatureReference	[LiteratureReference:9948394] Identification of a novel trigger complex that facilitates ribosome-associated quality control in mammalian cells
maxDepth	2
modified	[InstanceEdit:9948435] May, Bruce, 2025-05-20
name	RQT complex ASCC2:ASCC3:TRIP4
producedByEvent	[Reaction:R-HSA-9948300] RQT complex:K63polyUb-80S ribosome dissociates yielding K63polyUb-40S subunit and 60S subunit:peptidyl-tRNA with nascent peptide - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-9948297

Referrals

(input)	[Reaction:R-HSA-9948291] RQT complex binds K63polyUb-80S ribosome:no-go mRNA:peptidyl-tRNA with nascent peptide
(output)	[Reaction:R-HSA-9948300] RQT complex:K63polyUb-80S ribosome dissociates yielding K63polyUb-40S subunit and 60S subunit:peptidyl-tRNA with nascent peptide
(hasComponent)	[Complex:R-HSA-9948295] RQT complex:K63polyUb-80S Ribosome:no-go mRNA:peptidyl tRNA with nascent peptide [cytosol]

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