Reactome | GBP1 hydrolyzes GDP

Schema > Reaction > Entries

GBP1 hydrolyzes GDP Show undefined attributes

authored	[InstanceEdit:9963520] Shamovsky, Veronica, 2025-08-14
catalystActivity	[CatalystActivity:9947947] GDP phosphatase activity of GBP1 oligomer:GDP:LPS [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9947847] Shamovsky, Veronica, 2025-05-14
dbId	9947887
displayName	GBP1 hydrolyzes GDP
edited	[InstanceEdit:9970963] Shamovsky, Veronica, 2025-11-03
entityOnOtherCell	[SimpleEntity:R-ALL-6803081] LPS [peptidoglycan-based cell wall]
eventOf	[Pathway:R-HSA-9953170] GBP-mediated host defense - Homo sapiens
followingEvent	[Reaction:R-HSA-9953173] GMP dissociates from the GBP1 oligomer - Homo sapiens
input	[Complex:R-HSA-9947863] GBP1 oligomer:GDP:LPS [cytosol] 2 × [SimpleEntity:R-ALL-29356] H2O [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9947931] How guanylate-binding proteins achieve assembly-stimulated processive cleavage of GTP to GMP [LiteratureReference:9953141] The interferon-induced 67-kDa guanylate-binding protein (hGBP1) is a GTPase that converts GTP to GMP [LiteratureReference:9947890] Structural insights into the activation mechanism of antimicrobial GBP1 [LiteratureReference:9947914] Catalytic activity of human guanylate-binding protein 1 coupled to the release of structural restraints imposed by the C-terminal domain
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	GBP1 hydrolyzes GDP
orthologousEvent	[Reaction:R-DDI-9947887] GBP1 hydrolyzes GDP - Dictyostelium discoideum [Reaction:R-GGA-9947887] GBP1 hydrolyzes GDP - Gallus gallus [Reaction:R-XTR-9947887] GBP1 hydrolyzes GDP - Xenopus tropicalis [Reaction:R-DRE-9947887] GBP1 hydrolyzes GDP - Danio rerio [Reaction:R-SSC-9947887] GBP1 hydrolyzes GDP - Sus scrofa [Reaction:R-BTA-9947887] GBP1 hydrolyzes GDP - Bos taurus [Reaction:R-CFA-9947887] GBP1 hydrolyzes GDP - Canis familiaris [Reaction:R-RNO-9947887] GBP1 hydrolyzes GDP - Rattus norvegicus
output	[Complex:R-HSA-9947870] GBP1 oligomer:GMP:LPS [cytosol] 2 × [SimpleEntity:R-ALL-70106] H+ [cytosol] 2 × [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Polymerisation:R-HSA-9947842] GBP1 hydrolyzes GTP forming GBP1 oligomers - Homo sapiens
releaseDate	2025-12-08
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9970618] Daumke, Oliver, 2025-10-31
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9947887
summation	[Summation:9953142] Guanylate-binding protein 1 (GBP1) catalyzes a two-step GTP ...

Referrals

(hasEvent)	[Pathway:R-HSA-9953170] GBP-mediated host defense
(precedingEvent)	[Reaction:R-HSA-9953173] GMP dissociates from the GBP1 oligomer