Reactome | CRPPA dimer transfers cytidylyl to Rbt5P

Schema > Reaction > Entries

CRPPA dimer transfers cytidylyl to Rbt5P Show undefined attributes

authored	[InstanceEdit:9939469] Stephan, Ralf, 2025-02-27
catalystActivity	[CatalystActivity:9940820] D-ribitol-5-phosphate cytidylyltransferase activity of CRPPA dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9940703] Stephan, Ralf, 2025-03-06
crossReference	[DatabaseIdentifier:12668340] RHEA:12457 [DatabaseIdentifier:9940785] RHEA:12457
dbId	9940844
displayName	CRPPA dimer transfers cytidylyl to Rbt5P
edited	[InstanceEdit:9947109] Stephan, Ralf, 2025-05-01
eventOf	[Pathway:R-HSA-9939291] Matriglycan biosynthesis on DAG1 - Homo sapiens
followingEvent	[Reaction:R-HSA-9940804] SLC35A1,4 import CDP-ribitol - Homo sapiens
input	[SimpleEntity:R-ALL-110614] CTP [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-9940782] Rbo5P [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9940672] Human ISPD Is a Cytidyltransferase Required for Dystroglycan O-Mannosylation [LiteratureReference:9940787] Molecular Identification of d-Ribulokinase in Budding Yeast and Mammals [LiteratureReference:9940680] ISPD loss-of-function mutations disrupt dystroglycan O-mannosylation and cause Walker-Warburg syndrome [LiteratureReference:9940656] Limb-girdle muscular dystrophy with ?-dystroglycan deficiency and mutations in the ISPD gene [LiteratureReference:9940755] The functional O-mannose glycan on ?-dystroglycan contains a phospho-ribitol primed for matriglycan addition
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	CRPPA dimer transfers cytidylyl to Rbt5P
orthologousEvent	[Reaction:R-GGA-9940844] CRPPA dimer transfers cytidylyl to Rbt5P - Gallus gallus [Reaction:R-XTR-9940844] CRPPA dimer transfers cytidylyl to Rbt5P - Xenopus tropicalis [Reaction:R-DRE-9940844] CRPPA dimer transfers cytidylyl to Rbt5P - Danio rerio [Reaction:R-SSC-9940844] CRPPA dimer transfers cytidylyl to Rbt5P - Sus scrofa [Reaction:R-BTA-9940844] CRPPA dimer transfers cytidylyl to Rbt5P - Bos taurus [Reaction:R-CFA-9940844] CRPPA dimer transfers cytidylyl to Rbt5P - Canis familiaris [Reaction:R-RNO-9940844] CRPPA dimer transfers cytidylyl to Rbt5P - Rattus norvegicus [Reaction:R-MMU-9940844] CRPPA dimer transfers cytidylyl to Rbt5P - Mus musculus
output	[SimpleEntity:R-ALL-9940836] CDP-ribitol [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2025-06-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9947107] Zaru, Rossana, 2025-05-01
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9940844
summation	[Summation:9940653] D-ribitol-5-phosphate cytidylyltransferase (CRPPA) homodimer...

Referrals

(hasEvent)	[Pathway:R-HSA-9939291] Matriglycan biosynthesis on DAG1
(precedingEvent)	[Reaction:R-HSA-9940804] SLC35A1,4 import CDP-ribitol