Reactome | Mitochondrial ribosome-associated quality control

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Mitochondrial ribosome-associated quality control Show undefined attributes

authored	[InstanceEdit:9937408] May, Bruce, 2025-01-29
created	[InstanceEdit:9937368] May, Bruce, 2025-01-31
crossReference	[DatabaseIdentifier:12819585] BioModels Database:BIOMD0000000602
dbId	9937383
displayName	Mitochondrial ribosome-associated quality control
doi	10.3180/R-HSA-9937383.1
edited	[InstanceEdit:9937408] May, Bruce, 2025-01-29
eventOf	[Pathway:R-HSA-5368287] Mitochondrial translation - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:383674] mitochondrial translational termination
hasDiagram	true
hasEHLD	false
hasEvent	[BlackBoxEvent:R-HSA-9937412] Stalled 55S mitochondrial ribosome is dissociated to yield 28S subunit and 39S subunit:mRNA:peptidyl-tRNA:tRNA - Homo sapiens [Reaction:R-HSA-9937403] MTRFR:MTRES1 binds 39S ribosomal subunit:mRNA:peptidyl-tRNA:tRNA:MALSU1:MIEF1:NDUFAB1 - Homo sapiens [BlackBoxEvent:R-HSA-9937374] MTRFR:MTRES1:39S ribosomal subunit:mRNA:peptidyl-tRNA:MALSU1:MIEF1:NDUFAB1 dissociates - Homo sapiens [Reaction:R-HSA-9937724] 55S mitochondrial ribosome:non-stop mRNA binds ICT1 (MRPL58) - Homo sapiens [Reaction:R-HSA-9937719] ICT1 hydrolyzes the peptidyl-tRNA bond of the nascent polypeptide - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9937389] Elongational stalling activates mitoribosome-associated quality control [LiteratureReference:9937654] Detecting and Rescuing Stalled Ribosomes [LiteratureReference:9937652] Maintaining mitochondrial ribosome function: The role of ribosome rescue and recycling factors [LiteratureReference:5432606] A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome [LiteratureReference:9937722] Human Cells Require Non-stop Ribosome Rescue Activity in Mitochondria
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	Mitochondrial ribosome-associated quality control
orthologousEvent	[Pathway:R-CFA-9937383] Mitochondrial ribosome-associated quality control - Canis familiaris [Pathway:R-CEL-9937383] Mitochondrial ribosome-associated quality control - Caenorhabditis elegans [Pathway:R-DME-9937383] Mitochondrial ribosome-associated quality control - Drosophila melanogaster [Pathway:R-GGA-9937383] Mitochondrial ribosome-associated quality control - Gallus gallus [Pathway:R-XTR-9937383] Mitochondrial ribosome-associated quality control - Xenopus tropicalis [Pathway:R-DRE-9937383] Mitochondrial ribosome-associated quality control - Danio rerio [Pathway:R-SSC-9937383] Mitochondrial ribosome-associated quality control - Sus scrofa [Pathway:R-BTA-9937383] Mitochondrial ribosome-associated quality control - Bos taurus [Pathway:R-RNO-9937383] Mitochondrial ribosome-associated quality control - Rattus norvegicus [Pathway:R-MMU-9937383] Mitochondrial ribosome-associated quality control - Mus musculus
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2025-06-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9948130] Keiler, Kenneth C, 2025-05-16 [InstanceEdit:9948133] Seerpatham, Divyasorubini, 2025-05-16
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9937383
summation	[Summation:9937664] Translation can stall due to lack of tRNAs or due to defects...

Referrals

(hasEvent)

[Pathway:R-HSA-5368287] Mitochondrial translation

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