Reactome | ?-amyloid fibril:Zn2+ [extracellular region]

Schema > Complex > Entries

compartment	[Compartment:984] extracellular region
componentOf	[Complex:R-HSA-9936901] factor XII:?-amyloid fibril:Zn2+ [extracellular region] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-9936699] fibrinogen + ?-amyloid fibril:Zn2+ -> fibrinogen:?-amyloid fibril:Zn2+ - Homo sapiens [Reaction:R-HSA-9936909] factor XII + ?-amyloid fibril:Zn2+ -> factor XII:?-amyloid fibril:Zn2+ - Homo sapiens [Reaction:R-HSA-9939011] Lecanemab binds amyloid ? protein (APP) protofibrils - Homo sapiens
created	[InstanceEdit:9936677] Shamovsky, Veronica, 2025-01-25
crossReference	[DatabaseIdentifier:12020757] Mondo:0004975
dbId	9936695
disease	[Disease:8863054] Alzheimer's disease
displayName	?-amyloid fibril:Zn2+ [extracellular region]
hasComponent	[Polymer:R-HSA-976748] Beta amyloid fibril [extracellular region] [SimpleEntity:R-ALL-158417] Zn2+ [extracellular region]
inDisease	true
isChimeric	false
maxDepth	4
name	?-amyloid fibril:Zn2+ APP(672-713), APP(672-711):Zn2+ A?:Zn2+ aggregates
producedByEvent	[Reaction:R-HSA-9936906] factor XII:?-amyloid:Zn2+-> factor XIIa + ?-amyloid:Zn2+ (autocatalysis) - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-9936695
summation	[Summation:9936678] Chelation of metal ions, notably copper, iron and zinc, can ...

(output)	[Reaction:R-HSA-9936906] factor XII:?-amyloid:Zn2+-> factor XIIa + ?-amyloid:Zn2+ (autocatalysis)
(hasComponent)	[Complex:R-HSA-9936901] factor XII:?-amyloid fibril:Zn2+ [extracellular region] [Complex:R-HSA-9936697] fibrinogen:?-amyloid fibril:Zn2+ [extracellular region] [Complex:R-HSA-9939014] lecanemab:A? protofibrils [extracellular region]
(input)	[Reaction:R-HSA-9936909] factor XII + ?-amyloid fibril:Zn2+ -> factor XII:?-amyloid fibril:Zn2+ [Reaction:R-HSA-9936699] fibrinogen + ?-amyloid fibril:Zn2+ -> fibrinogen:?-amyloid fibril:Zn2+ [Reaction:R-HSA-9939011] Lecanemab binds amyloid ? protein (APP) protofibrils