Reactome | Ubiquitinated CDH1 is endocytosed

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Ubiquitinated CDH1 is endocytosed Show undefined attributes

authored	[InstanceEdit:9934754] Orlic-Milacic, Marija, 2025-01-10
category	uncertain
compartment	[Compartment:876] plasma membrane [Compartment:74700] endosome membrane
created	[InstanceEdit:9934754] Orlic-Milacic, Marija, 2025-01-10
dbId	9934752
displayName	Ubiquitinated CDH1 is endocytosed
edited	[InstanceEdit:9935645] Orlic-Milacic, Marija, 2025-01-17
eventOf	[Pathway:R-HSA-9958810] SRC activates STAT3 in a quantitative manner, through Cadherin-11 (CDH11), RAC1 and gp130 (IL6ST) - Homo sapiens [Pathway:R-HSA-9766229] Degradation of CDH1 - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9935552] Ubiquitinated CDH1 translocates to lysosomes for degradation - Homo sapiens
input	[Complex:R-HSA-9935237] CBLL1:PolyUb-p-2Y-CDH1 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9935106] Reduced surface expression of epithelial E-cadherin evoked by interferon-gamma is Fyn kinase-dependent [LiteratureReference:9934839] An acidic extracellular pH disrupts adherens junctions in HepG2 cells by Src kinases-dependent modification of E-cadherin [LiteratureReference:9935502] Cdc42 regulates E-cadherin ubiquitination and degradation through an epidermal growth factor receptor to Src-mediated pathway
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Ubiquitinated CDH1 is endocytosed
orthologousEvent	[BlackBoxEvent:R-GGA-9934752] Ubiquitinated CDH1 is endocytosed - Gallus gallus [BlackBoxEvent:R-DRE-9934752] Ubiquitinated CDH1 is endocytosed - Danio rerio [BlackBoxEvent:R-SSC-9934752] Ubiquitinated CDH1 is endocytosed - Sus scrofa [BlackBoxEvent:R-BTA-9934752] Ubiquitinated CDH1 is endocytosed - Bos taurus [BlackBoxEvent:R-CFA-9934752] Ubiquitinated CDH1 is endocytosed - Canis familiaris [BlackBoxEvent:R-RNO-9934752] Ubiquitinated CDH1 is endocytosed - Rattus norvegicus [BlackBoxEvent:R-MMU-9934752] Ubiquitinated CDH1 is endocytosed - Mus musculus
output	[Complex:R-HSA-9935413] CBLL1:PolyUb-p-2Y-CDH1 [early endosome membrane]
precedingEvent	[Reaction:R-HSA-9934753] CBLL1 ubiquitinates CDH1 - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2025-06-18
releaseStatus	UPDATED
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9975417] Raptis, Leda, 2025-11-21
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9934752
summation	[Summation:9935073] Ectopic overexpression of a recombinant mouse CBLL1 (Hakai),...
updateTrackers	[UpdateTracker:9984619] Update Tracker - [BlackBoxEvent:9934752] Ubiquitinated CDH1 is endocytosed - v96:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9984619] Update Tracker - [BlackBoxEvent:9934752] Ubiquitinated CDH1 is endocytosed - v96:[modifyText]
(hasEvent)	[Pathway:R-HSA-9958810] SRC activates STAT3 in a quantitative manner, through Cadherin-11 (CDH11), RAC1 and gp130 (IL6ST) [Pathway:R-HSA-9766229] Degradation of CDH1
(precedingEvent)	[BlackBoxEvent:R-HSA-9935552] Ubiquitinated CDH1 translocates to lysosomes for degradation