Reactome | CTNNB1, JUP bind CDH1

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CTNNB1, JUP bind CDH1 Show undefined attributes

authored	[InstanceEdit:9933195] Orlic-Milacic, Marija, 2024-12-27
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:9933195] Orlic-Milacic, Marija, 2024-12-27
dbId	9933194
displayName	CTNNB1, JUP bind CDH1
edited	[InstanceEdit:9935645] Orlic-Milacic, Marija, 2025-01-17
eventOf	[Pathway:R-HSA-9768727] Regulation of CDH1 posttranslational processing and trafficking to plasma membrane - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9816273] CDH1 translocates from ER to Golgi - Homo sapiens
input	[DefinedSet:R-HSA-9934368] CTNNB1,JUP [cytosol] 2 × [EntityWithAccessionedSequence:R-HSA-9933653] Man,Man9GlucNAc2,p-3S-CDH1(23-882) [endoplasmic reticulum membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9933207] E-cadherin/catenin complexes are formed cotranslationally in the endoplasmic reticulum/Golgi compartments [LiteratureReference:9816226] Cytoplasmic O-glycosylation prevents cell surface transport of E-cadherin during apoptosis [LiteratureReference:9762154] Adhesive but not lateral E-cadherin complexes require calcium and catenins for their formation [LiteratureReference:9762176] Distinct cadherin-catenin complexes in Ca(2+)-dependent cell-cell adhesion
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	CTNNB1, JUP bind CDH1
orthologousEvent	[Reaction:R-GGA-9933194] CTNNB1, JUP bind CDH1 - Gallus gallus [Reaction:R-XTR-9933194] CTNNB1, JUP bind CDH1 - Xenopus tropicalis [Reaction:R-DRE-9933194] CTNNB1, JUP bind CDH1 - Danio rerio [Reaction:R-SSC-9933194] CTNNB1, JUP bind CDH1 - Sus scrofa [Reaction:R-BTA-9933194] CTNNB1, JUP bind CDH1 - Bos taurus [Reaction:R-CFA-9933194] CTNNB1, JUP bind CDH1 - Canis familiaris [Reaction:R-RNO-9933194] CTNNB1, JUP bind CDH1 - Rattus norvegicus [Reaction:R-MMU-9933194] CTNNB1, JUP bind CDH1 - Mus musculus
output	[DefinedSet:R-HSA-9934362] Man,Man9GlucNAc2,p-3S-CDH1(23-882):CTNNB1,JUP [endoplasmic reticulum membrane]
precedingEvent	[BlackBoxEvent:R-HSA-9816277] CDH1 is O-manosylated - Homo sapiens [Reaction:R-HSA-9933380] Cytosolic tail of CDH1 is phosphorylated - Homo sapiens
releaseDate	2025-06-18
reviewStatus	[ReviewStatus:9821383] three stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9933194
summation	[Summation:9933204] CTNNB1 (beta-catenin) was shown to associate with the cyt...

Referrals

(hasEvent)	[Pathway:R-HSA-9768727] Regulation of CDH1 posttranslational processing and trafficking to plasma membrane
(precedingEvent)	[BlackBoxEvent:R-HSA-9816273] CDH1 translocates from ER to Golgi