Reactome | Anti-TFPI antibody binds TFPI?

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Anti-TFPI antibody binds TFPI? Show undefined attributes

authored	[InstanceEdit:9931616] Shamovsky, Veronica, 2024-12-12
category	binding
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:9931616] Shamovsky, Veronica, 2024-12-12
crossReference	[DatabaseIdentifier:12020767] Mondo:0001531
dbId	9931618
disease	[Disease:9696604] blood coagulation disease
displayName	Anti-TFPI antibody binds TFPI?
edited	[InstanceEdit:9937613] Shamovsky, Veronica, 2025-02-05
eventOf	[Pathway:R-HSA-9769739] Regulation of clotting cascade - Homo sapiens
input	[DefinedSet:R-ALL-9934900] anti-TFPI [extracellular region] [EntityWithAccessionedSequence:R-HSA-9931632] TFPI? [extracellular region]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9931653] Hemostatic properties of a TFPI antibody [LiteratureReference:9931629] Concizumab restores thrombin generation potential in patients with haemophilia: Pharmacokinetic/pharmacodynamic modelling results of concizumab phase 1/1b data [LiteratureReference:9931676] Concizumab improves clot formation in hemophilia A under flow [LiteratureReference:9931619] Concizumab as a Subcutaneous Prophylactic Treatment Option for Patients with Hemophilia A or B: A Review of the Evidence and Patient's Perspectives [LiteratureReference:9931686] Tissue factor pathway inhibitor: structure-function [LiteratureReference:9934907] Marstacimab, a tissue factor pathway inhibitor neutralizing antibody, improves coagulation parameters of ex vivo dosed haemophilic blood and plasmas
maxDepth	1
modified	[InstanceEdit:9980322] Shamovsky, Veronica, 2026-01-27
name	Anti-TFPI antibody binds TFPI?
output	[Complex:R-HSA-9931660] TFPI?:anti-TFPI [extracellular region]
releaseDate	2026-03-25
releaseStatus	NEW
reviewStatus	[ReviewStatus:9821383] three stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9931618
summation	[Summation:9931681] Concizumab (Alhemo�) and marstacimab (Hympavzi�) are humaniz...

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[Pathway:R-HSA-9769739] Regulation of clotting cascade