Reactome | MITF-M-dependent GXYLT2 gene expression

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MITF-M-dependent GXYLT2 gene expression Show undefined attributes

authored	[InstanceEdit:9927254] Vu, Hong Nhung, 2024-11-05 [InstanceEdit:9927252] Steingr�msson, Eir�kur, 2024-11-05
category	omitted
compartment	[Compartment:7660] nucleoplasm [Compartment:876] plasma membrane
created	[InstanceEdit:9926531] Rothfels, Karen, 2024-11-01
dbId	9926530
displayName	MITF-M-dependent GXYLT2 gene expression
edited	[InstanceEdit:9927257] Rothfels, Karen, 2024-11-05
eventOf	[Pathway:R-HSA-9926550] Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-9926331] GXYLT2 gene [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9926252] MITF reprograms the extracellular matrix and focal adhesion in melanoma [LiteratureReference:9907019] Transcription factor MITF and remodeller BRG1 define chromatin organisation at regulatory elements in melanoma cells [LiteratureReference:9926271] Enhancer-targeted genome editing selectively blocks innate resistance to oncokinase inhibition [LiteratureReference:9927090] A potential target of GXYLT2 affecting the prognosis of gastric cancer by enhancing the EMT process: A clinical retrospective study [LiteratureReference:9927109] GXYLT2 accelerates cell growth and migration by regulating the Notch pathway in human cancer cells [LiteratureReference:9927102] Identification of glycosyltransferase 8 family members as xylosyltransferases acting on O-glucosylated notch epidermal growth factor repeats [LiteratureReference:9927088] Pan-cancer analysis of the prognostic significance and oncogenic role of GXYLT2
maxDepth	1
modified	[InstanceEdit:9927681] Rothfels, Karen, 2024-11-08
name	MITF-M-dependent GXYLT2 gene expression
output	[EntityWithAccessionedSequence:R-HSA-9926322] GXYLT2 [plasma membrane]
precedingEvent	[Reaction:R-HSA-9926477] MITF-M binds GXYLT2 gene - Homo sapiens
regulatedBy	[NegativeGeneExpressionRegulation:9926451] Negative gene expression regulation by 'MITF-M dimer:GXYLT2 gene [nucleoplasm]'
regulationReference	[RegulationReference:9926467] Negative gene expression regulation by 'MITF-M dimer:GXYLT2 gene [nucleoplasm]' MITF reprograms the extracellular matrix and focal adhesion in melanoma
releaseDate	2024-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9927254] Vu, Hong Nhung, 2024-11-05 [InstanceEdit:9927252] Steingr�msson, Eir�kur, 2024-11-05
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9926530
summation	[Summation:9927092] MITF-M is implicated as a direct repressor of GXYLT2 express...

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[Pathway:R-HSA-9926550] Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition

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