Reactome | UBE2I sumoylates MITF-M

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UBE2I sumoylates MITF-M Show undefined attributes

authored	[InstanceEdit:9927254] Vu, Hong Nhung, 2024-11-05 [InstanceEdit:9927252] Steingr�msson, Eir�kur, 2024-11-05
catalystActivity	[CatalystActivity:2997650] SUMO transferase activity of SUMO1:C93-UBE2I [nucleoplasm]
catalystActivityReference	[CatalystActivityReference:9926432] SUMO transferase activity of SUMO1:C93-UBE2I [nucleoplasm] Sumoylation modulates transcriptional activity of MITF in a promoter-specific manner
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9926473] Rothfels, Karen, 2024-11-01
dbId	9926476
displayName	UBE2I sumoylates MITF-M
edited	[InstanceEdit:9927257] Rothfels, Karen, 2024-11-05
eventOf	[Pathway:R-HSA-9856649] Transcriptional and post-translational regulation of MITF-M expression and activity - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-9824664] MITF-M [nucleoplasm] 2 × [Complex:R-HSA-2993783] SUMO1:C93-UBE2I [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9926234] Sumoylation modulates transcriptional activity of MITF in a promoter-specific manner [LiteratureReference:3232149] Sumoylation of MITF and its related family members TFE3 and TFEB
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	UBE2I sumoylates MITF-M
orthologousEvent	[Reaction:R-SCE-9926476] UBE2I sumoylates MITF-M - Saccharomyces cerevisiae [Reaction:R-CEL-9926476] UBE2I sumoylates MITF-M - Caenorhabditis elegans [Reaction:R-GGA-9926476] UBE2I sumoylates MITF-M - Gallus gallus [Reaction:R-DRE-9926476] UBE2I sumoylates MITF-M - Danio rerio [Reaction:R-SSC-9926476] UBE2I sumoylates MITF-M - Sus scrofa [Reaction:R-BTA-9926476] UBE2I sumoylates MITF-M - Bos taurus [Reaction:R-RNO-9926476] UBE2I sumoylates MITF-M - Rattus norvegicus [Reaction:R-MMU-9926476] UBE2I sumoylates MITF-M - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-9926335] monoSUMO1-K182,318 MITF-M [nucleoplasm] 2 × [EntityWithAccessionedSequence:R-HSA-912481] UBE2I [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-9730412] MITF gene expression - Homo sapiens [Reaction:R-HSA-2993780] Transfer of SUMO1 from E1 to UBE2I (UBC9) - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2024-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9927254] Vu, Hong Nhung, 2024-11-05 [InstanceEdit:9927252] Steingr�msson, Eir�kur, 2024-11-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9926476
summation	[Summation:9926320] MITF-M is sumoylated at residues 182 and 316 (Miller et al, ...

Referrals

(hasEvent)

[Pathway:R-HSA-9856649] Transcriptional and post-translational regulation of MITF-M expression and activity