Reactome | Phosphorylated BMAL1:CLOCK and coactivators positively regulate expression of Cryptochrome-2 (CRY2)

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Phosphorylated BMAL1:CLOCK and coactivators positively regulate expression of Cryptochrome-2 (CRY2) Show undefined attributes

authored	[InstanceEdit:9925657] May, Bruce, 2024-10-20
category	uncertain
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:9925645] May, Bruce, 2024-10-21
dbId	9925647
deleted	[Deleted:9938728] Deletion of instance: 549470
displayName	Phosphorylated BMAL1:CLOCK and coactivators positively regulate expression of Cryptochrome-2 (CRY2)
edited	[InstanceEdit:9925657] May, Bruce, 2024-10-20
eventOf	[Pathway:R-HSA-9931510] Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9909392] Formation of CRY:PER:Kinase complex - Homo sapiens
inferredFrom	[BlackBoxEvent:R-MMU-9926580] Phosphorylated Bmal1:Clock and coactivators positively regulate expression of Cry2 - Mus musculus
input	[EntityWithAccessionedSequence:R-HSA-5641201] CRY2 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
maxDepth	1
modified	[InstanceEdit:9938697] May, Bruce, 2025-02-18
name	Phosphorylated BMAL1:CLOCK and coactivators positively regulate expression of Cryptochrome-2 (CRY2)
output	[EntityWithAccessionedSequence:R-HSA-400255] CRY2 [cytosol]
precedingEvent	[Reaction:R-HSA-9925650] p-S90-BMAL1:p-T451,T461-CLOCK and coactivators bind the CRY2 gene - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
regulatedBy	[PositiveGeneExpressionRegulation:9925646] Positive gene expression regulation by 'p-S90-BMAL1:p-T451,T461-CLOCK:CREBBP:KMT2A:CRY2 gene [nucleoplasm]'
releaseDate	2025-03-26
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9938389] Sancar, Aziz, 2025-02-14 [InstanceEdit:9938694] Albrecht, Urs, 2025-02-18
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9925647
summation	[Summation:9929276] Phosphorylated BMAL1:CLOCK and the histone acetyltransferase...

Referrals

(replacementInstances)	[Deleted:9938728] Deletion of instance: 549470
(precedingEvent)	[BlackBoxEvent:R-HSA-9909392] Formation of CRY:PER:Kinase complex
(hasEvent)	[Pathway:R-HSA-9931510] Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes
(inferredTo)	[BlackBoxEvent:R-MMU-9926580] Phosphorylated Bmal1:Clock and coactivators positively regulate expression of Cry2

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