Reactome | TTC19 clears UQCRFS1 fragments from Complex III

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TTC19 clears UQCRFS1 fragments from Complex III Show undefined attributes

authored	[InstanceEdit:9906026] Stephan, Ralf, 2024-03-29
category	uncertain
compartment	[Compartment:70616] mitochondrial inner membrane
created	[InstanceEdit:9906044] Stephan, Ralf, 2024-03-29
dbId	9906042
displayName	TTC19 clears UQCRFS1 fragments from Complex III
edited	[InstanceEdit:9910822] Stephan, Ralf, 2024-05-21
eventOf	[Pathway:R-HSA-9865881] Complex III assembly - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:161873] protein stabilization
input	[Complex:R-HSA-9906014] Dimer of Late core complex:UQCR10:UQCR11:holo-UQCRFS1(79-274):Fragments [mitochondrial inner membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9906025] TTC19 Plays a Husbandry Role on UQCRFS1 Turnover in the Biogenesis of Mitochondrial Respiratory Complex III [LiteratureReference:9866265] Mitochondrial complex III Rieske Fe-S protein processing and assembly [LiteratureReference:9906043] Mutations in TTC19 cause mitochondrial complex III deficiency and neurological impairment in humans and flies [LiteratureReference:9906053] A TTC19 mutation associated with progressive movement disorders and peripheral neuropathy: Case report and systematic review
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	TTC19 clears UQCRFS1 fragments from Complex III
orthologousEvent	[BlackBoxEvent:R-RNO-9906042] TTC19 clears UQCRFS1 fragments from Complex III - Rattus norvegicus [BlackBoxEvent:R-CEL-9906042] TTC19 clears UQCRFS1 fragments from Complex III - Caenorhabditis elegans [BlackBoxEvent:R-DME-9906042] TTC19 clears UQCRFS1 fragments from Complex III - Drosophila melanogaster [BlackBoxEvent:R-GGA-9906042] TTC19 clears UQCRFS1 fragments from Complex III - Gallus gallus [BlackBoxEvent:R-DRE-9906042] TTC19 clears UQCRFS1 fragments from Complex III - Danio rerio [BlackBoxEvent:R-SSC-9906042] TTC19 clears UQCRFS1 fragments from Complex III - Sus scrofa [BlackBoxEvent:R-BTA-9906042] TTC19 clears UQCRFS1 fragments from Complex III - Bos taurus [BlackBoxEvent:R-MMU-9906042] TTC19 clears UQCRFS1 fragments from Complex III - Mus musculus
output	[Complex:R-HSA-9866171] Cytochrome c reductase [mitochondrial inner membrane] 2 × [OtherEntity:R-ALL-9906010] Unspecified N-terminal UQCRFS1 fragments [mitochondrial inner membrane]
precedingEvent	[BlackBoxEvent:R-HSA-9906017] Unknown peptidase cleaves UQCRFS1 subunit - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
regulatedBy	[Requirement:9906049] Requirement by 'TTC19 [mitochondrial inner membrane]'
regulationReference	[RegulationReference:9906050] Requirement by 'TTC19 [mitochondrial inner membrane]' TTC19 Plays a Husbandry Role on UQCRFS1 Turnover in the Biogenesis of Mitochondrial Respiratory Complex III
releaseDate	2024-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9910688] Hill, David P, 2024-05-16
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9906042
summation	[Summation:9906048] N-terminal cleavage fragments of UQCRFS1 are cleared by TTC1...

Referrals

(hasEvent)

[Pathway:R-HSA-9865881] Complex III assembly