Reactome | MITF-M-dependent ATP6V1E1 gene expression

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MITF-M-dependent ATP6V1E1 gene expression Show undefined attributes

authored	[InstanceEdit:9856650] Rothfels, Karen, 2023-12-21
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:9858937] Rothfels, Karen, 2024-01-14
dbId	9858923
displayName	MITF-M-dependent ATP6V1E1 gene expression
edited	[InstanceEdit:9856650] Rothfels, Karen, 2023-12-21
eventOf	[Pathway:R-HSA-9857377] Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-9858784] ATP6V1E1 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9857261] Mitf is a master regulator of the v-ATPase, forming a control module for cellular homeostasis with v-ATPase and TORC1 [LiteratureReference:9858868] Novel roles for the MiTF/TFE family of transcription factors in organelle biogenesis, nutrient sensing, and energy homeostasis [LiteratureReference:9858862] Rag GTPases mediate amino acid-dependent recruitment of TFEB and MITF to lysosomes [LiteratureReference:9824935] MITF drives endolysosomal biogenesis and potentiates Wnt signaling in melanoma cells [LiteratureReference:9857242] MITF has a central role in regulating starvation-induced autophagy in melanoma [LiteratureReference:9857267] The MITF family of transcription factors: Role in endolysosomal biogenesis, Wnt signaling, and oncogenesis [LiteratureReference:9730403] MITF-the first 25 years
maxDepth	1
modified	[InstanceEdit:9927681] Rothfels, Karen, 2024-11-08
name	MITF-M-dependent ATP6V1E1 gene expression
output	[EntityWithAccessionedSequence:R-HSA-912606] ATP6V1E1 [cytosol]
precedingEvent	[Reaction:R-HSA-9858883] MITF-M binds the promoters of v-ATPase target genes - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
regulatedBy	[PositiveGeneExpressionRegulation:9858929] Positive gene expression regulation by 'MITF-M dimer:ATP6V1E1 gene [nucleoplasm]'
regulationReference	[RegulationReference:9858938] Positive gene expression regulation by 'MITF-M dimer:ATP6V1E1 gene [nucleoplasm]' Mitf is a master regulator of the v-ATPase, forming a control module for cellular homeostasis with v-ATPase and TORC1
releaseDate	2024-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9863245] Arnheiter, Heinz, 2024-02-26 [InstanceEdit:9910860] de la Serna, Ivana L, 2024-05-21 [InstanceEdit:9927254] Vu, Hong Nhung, 2024-11-05 [InstanceEdit:9927252] Steingr�msson, Eir�kur, 2024-11-05
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9858923
summation	[Summation:9859442] MITF has been implicated in the regulation of expression of ...

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(hasEvent)

[Pathway:R-HSA-9857377] Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy