Reactome | miR-211 RISC binds POU3F2 mRNA

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miR-211 RISC binds POU3F2 mRNA Show undefined attributes

authored	[InstanceEdit:9856650] Rothfels, Karen, 2023-12-21
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9858306] Rothfels, Karen, 2024-01-10
dbId	9858309
displayName	miR-211 RISC binds POU3F2 mRNA
edited	[InstanceEdit:9856650] Rothfels, Karen, 2023-12-21
eventOf	[Pathway:R-HSA-9824594] Regulation of MITF-M-dependent genes involved in apoptosis - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9858308] miR-211 represses POU3F2 mRNA translation - Homo sapiens
input	[CandidateSet:R-HSA-9858271] mir-211 RISC [cytosol] [EntityWithAccessionedSequence:R-HSA-9858244] POU3F mRNA [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9858101] Chromosomal localization and genomic characterization of the mouse melastatin gene (Mlsn1) [LiteratureReference:9858114] Down-regulation of the novel gene melastatin correlates with potential for melanoma metastasis [LiteratureReference:9858152] Melastatin expression and prognosis in cutaneous malignant melanoma [LiteratureReference:9858166] New target genes of MITF-induced microRNA-211 contribute to melanoma cell invasion [LiteratureReference:9858199] miR-211 and MITF modulation by Bcl-2 protein in melanoma cells [LiteratureReference:9858124] Intronic miR-211 assumes the tumor suppressive function of its host gene in melanoma [LiteratureReference:9858145] Melanoma cell invasiveness is regulated by miR-211 suppression of the BRN2 transcription factor [LiteratureReference:9858093] Brn-2 represses microphthalmia-associated transcription factor expression and marks a distinct subpopulation of microphthalmia-associated transcription factor-negative melanoma cells [LiteratureReference:9858170] Oncogenic BRAF regulates melanoma proliferation through the lineage specific factor MITF [LiteratureReference:9858083] BRN2 suppresses apoptosis, reprograms DNA damage repair, and is associated with a high somatic mutation burden in melanoma [LiteratureReference:9730403] MITF-the first 25 years [LiteratureReference:9858088] BRN2, a POUerful driver of melanoma phenotype switching and metastasis
maxDepth	1
modified	[InstanceEdit:9927682] Rothfels, Karen, 2024-11-08
name	miR-211 RISC binds POU3F2 mRNA
output	[Complex:R-HSA-9858272] mir-211 RISC:POU3F2 mRNA [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-9858289] MITF-M-dependent miR-211 expression - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2024-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9863245] Arnheiter, Heinz, 2024-02-26 [InstanceEdit:9910860] de la Serna, Ivana L, 2024-05-21 [InstanceEdit:9927254] Vu, Hong Nhung, 2024-11-05 [InstanceEdit:9927252] Steingr�msson, Eir�kur, 2024-11-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9858309
summation	[Summation:9858305] miR-211 is an MITF-M-dependent target gene that is expressed...

Referrals

(hasEvent)	[Pathway:R-HSA-9824594] Regulation of MITF-M-dependent genes involved in apoptosis
(precedingEvent)	[BlackBoxEvent:R-HSA-9858308] miR-211 represses POU3F2 mRNA translation

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