Reactome | p-T153 USF1 dimer binds the TYR promoter

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p-T153 USF1 dimer binds the TYR promoter Show undefined attributes

authored	[InstanceEdit:9856650] Rothfels, Karen, 2023-12-21
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9855907] Rothfels, Karen, 2023-12-07
dbId	9855908
displayName	p-T153 USF1 dimer binds the TYR promoter
edited	[InstanceEdit:9856650] Rothfels, Karen, 2023-12-21
eventOf	[Pathway:R-HSA-9824585] Regulation of MITF-M-dependent genes involved in pigmentation - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9824579] MITF-M-dependent TYR gene expression - Homo sapiens
input	[Complex:R-HSA-9855890] pT153 USF1 dimer [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9824596] TYR gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9855320] Recognition of the E-C4 element from the C4 complement gene promoter by the upstream stimulatory factor-1 transcription factor [LiteratureReference:9855332] The Usf-1 transcription factor is a novel target for the stress-responsive p38 kinase and mediates UV-induced Tyrosinase expression [LiteratureReference:9855328] Target gene specificity of USF-1 is directed via p38-mediated phosphorylation-dependent acetylation [LiteratureReference:9855344] UV-induced expression of key component of the tanning process, the POMC and MC1R genes, is dependent on the p-38-activated upstream stimulating factor-1 (USF-1)
maxDepth	1
modified	[InstanceEdit:9927682] Rothfels, Karen, 2024-11-08
name	p-T153 USF1 dimer binds the TYR promoter
output	[Complex:R-HSA-9855892] pT153 USF1 dimer:TYR promoter [nucleoplasm]
precedingEvent	[Reaction:R-HSA-9855910] USF1 is phosphorylated by p-MAPK14 - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2024-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9910860] de la Serna, Ivana L, 2024-05-21 [InstanceEdit:9927254] Vu, Hong Nhung, 2024-11-05 [InstanceEdit:9927252] Steingr�msson, Eir�kur, 2024-11-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9855908
summation	[Summation:9855877] p-T153 USF1 binds to E- and M-box elements in the promoter o...

Referrals

(precedingEvent)	[BlackBoxEvent:R-HSA-9824579] MITF-M-dependent TYR gene expression
(hasEvent)	[Pathway:R-HSA-9824585] Regulation of MITF-M-dependent genes involved in pigmentation

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