Reactome | ANO5, ANO6 expose PS, PE on endothelial cells

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ANO5, ANO6 expose PS, PE on endothelial cells Show undefined attributes

authored	[InstanceEdit:9854637] Shamovsky, Veronica, 2023-11-28
catalystActivity	[CatalystActivity:9854667] phospholipid scramblase activity of ANO5:ANO5:Ca2+, ANO6:ANO6:Ca2+ [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9854630] phospholipid scramblase activity of ANO5, ANO6 [plasma membrane] TMEM16E regulates endothelial cell procoagulant activity and thrombosis
category	omitted
compartment	[Compartment:947587] cytoplasmic side of plasma membrane [Compartment:876] plasma membrane [Compartment:947586] external side of plasma membrane
created	[InstanceEdit:9854637] Shamovsky, Veronica, 2023-11-28
dbId	9854657
displayName	ANO5, ANO6 expose PS, PE on endothelial cells
edited	[InstanceEdit:9937613] Shamovsky, Veronica, 2025-02-05
eventOf	[Pathway:R-HSA-9769739] Regulation of clotting cascade - Homo sapiens
input	[DefinedSet:R-ALL-947588] APLs [cytoplasmic side of plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9854652] TMEM16E regulates endothelial cell procoagulant activity and thrombosis
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	ANO5, ANO6 expose PS, PE on endothelial cells
orthologousEvent	[BlackBoxEvent:R-SCE-9854657] ANO5, ANO6 expose PS, PE on endothelial cells - Saccharomyces cerevisiae [BlackBoxEvent:R-SPO-9854657] ANO5, ANO6 expose PS, PE on endothelial cells - Schizosaccharomyces pombe [BlackBoxEvent:R-DDI-9854657] ANO5, ANO6 expose PS, PE on endothelial cells - Dictyostelium discoideum [BlackBoxEvent:R-DME-9854657] ANO5, ANO6 expose PS, PE on endothelial cells - Drosophila melanogaster [BlackBoxEvent:R-GGA-9854657] ANO5, ANO6 expose PS, PE on endothelial cells - Gallus gallus [BlackBoxEvent:R-XTR-9854657] ANO5, ANO6 expose PS, PE on endothelial cells - Xenopus tropicalis [BlackBoxEvent:R-DRE-9854657] ANO5, ANO6 expose PS, PE on endothelial cells - Danio rerio [BlackBoxEvent:R-SSC-9854657] ANO5, ANO6 expose PS, PE on endothelial cells - Sus scrofa [BlackBoxEvent:R-BTA-9854657] ANO5, ANO6 expose PS, PE on endothelial cells - Bos taurus [BlackBoxEvent:R-CFA-9854657] ANO5, ANO6 expose PS, PE on endothelial cells - Canis familiaris [BlackBoxEvent:R-RNO-9854657] ANO5, ANO6 expose PS, PE on endothelial cells - Rattus norvegicus [BlackBoxEvent:R-MMU-9854657] ANO5, ANO6 expose PS, PE on endothelial cells - Mus musculus
output	[DefinedSet:R-ALL-947594] APLs [external side of plasma membrane]
releaseDate	2026-03-25
releaseStatus	NEW
requiredInputComponent	[SimpleEntity:R-ALL-140648] Ca2+ [plasma membrane]
reviewStatus	[ReviewStatus:9821383] three stars
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9854657
summation	[Summation:9854649] Anoctamin-5 (ANO5, also known as TMEM16E) and ANO6 (TMEM16F)...

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[Pathway:R-HSA-9769739] Regulation of clotting cascade