Reactome | NPM1-ALK;NPM1:FOXM1 [nucleoplasm]

Schema > Complex > Entries

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9850902] Rothfels, Karen, 2023-10-12
crossReference	[DatabaseIdentifier:12020842] Mondo:0020325
dbId	9850901
disease	[Disease:9699595] anaplastic large cell lymphoma [Disease:1500689] cancer
displayName	NPM1-ALK;NPM1:FOXM1 [nucleoplasm]
hasComponent	[EntityWithAccessionedSequence:R-HSA-4088019] FOXM1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-606320] NPM1 [nucleoplasm] [Complex:R-HSA-9725012] NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer [nucleoplasm]
inDisease	true
isChimeric	false
literatureReference	[LiteratureReference:9846077] NPM-ALK Is a Key Regulator of the Oncoprotein FOXM1 in ALK-Positive Anaplastic Large Cell Lymphoma
maxDepth	3
name	NPM1-ALK;NPM1:FOXM1
positivelyRegulates	[PositiveGeneExpressionRegulation:9850984] Positive gene expression regulation by 'NPM1-ALK;NPM1:FOXM1 [nucleoplasm]'
producedByEvent	[Reaction:R-HSA-9851090] NPM1-ALK binds NPM1 and FOXM1 - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-9850901

(output)	[Reaction:R-HSA-9851090] NPM1-ALK binds NPM1 and FOXM1
(regulator)	[PositiveGeneExpressionRegulation:9850984] Positive gene expression regulation by 'NPM1-ALK;NPM1:FOXM1 [nucleoplasm]'

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