Reactome | SETDB1 in me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1HS,L1PA2,3 heterochromatin trimethylates lysine-9 of histone H3 in adjacent nucleosome

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SETDB1 in me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1HS,L1PA2,3 heterochromatin trimethylates lysine-9 of histone H3 in adjacent nucleosome Show undefined attributes

authored	[InstanceEdit:9843969] May, Bruce, 2023-09-11
catalystActivity	[CatalystActivity:9844056] histone H3 methyltransferase activity of me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1HS,L1PA2,3:Nucleosome with H3K9me3 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9843957] May, Bruce, 2023-09-12
dbId	9844057
displayName	SETDB1 in me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1HS,L1PA2,3 heterochromatin trimethylates lysine-9 of histone H3 in adjacent nucleosome
edited	[InstanceEdit:9843969] May, Bruce, 2023-09-11
eventOf	[Pathway:R-HSA-9843970] Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex - Homo sapiens
input	6 × [SimpleEntity:R-ALL-77087] AdoMet [nucleoplasm] [Complex:R-HSA-427402] Nucleosome [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9843922] GENE SILENCING. Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells [LiteratureReference:9844043] Selective silencing of euchromatic L1s revealed by genome-wide screens for L1 regulators [LiteratureReference:9909778] ATF7IP-Mediated Stabilization of the Histone Methyltransferase SETDB1 Is Essential for Heterochromatin Formation by the HUSH Complex [LiteratureReference:9843984] Genome surveillance by HUSH-mediated silencing of intronless mobile elements
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	SETDB1 in me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1HS,L1PA2,3 heterochromatin trimethylates lysine-9 of histone H3 in adjacent nucleosome
orthologousEvent	[Reaction:R-GGA-9844057] SETDB1 in me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1HS,L1PA2,3 heterochromatin trimethylates lysine-9 of histone H3 in adjacent nucleosome - Gallus gallus [Reaction:R-XTR-9844057] SETDB1 in me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1HS,L1PA2,3 heterochromatin trimethylates lysine-9 of histone H3 in adjacent nucleosome - Xenopus tropicalis [Reaction:R-DRE-9844057] SETDB1 in me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1HS,L1PA2,3 heterochromatin trimethylates lysine-9 of histone H3 in adjacent nucleosome - Danio rerio [Reaction:R-SSC-9844057] SETDB1 in me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1HS,L1PA2,3 heterochromatin trimethylates lysine-9 of histone H3 in adjacent nucleosome - Sus scrofa [Reaction:R-BTA-9844057] SETDB1 in me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1HS,L1PA2,3 heterochromatin trimethylates lysine-9 of histone H3 in adjacent nucleosome - Bos taurus [Reaction:R-CFA-9844057] SETDB1 in me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1HS,L1PA2,3 heterochromatin trimethylates lysine-9 of histone H3 in adjacent nucleosome - Canis familiaris [Reaction:R-RNO-9844057] SETDB1 in me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1HS,L1PA2,3 heterochromatin trimethylates lysine-9 of histone H3 in adjacent nucleosome - Rattus norvegicus
output	6 × [SimpleEntity:R-ALL-77502] AdoHcy [nucleoplasm] [Complex:R-HSA-5625748] Nucleosome with H3K9me3 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-9843927] me3-K16-ATF7IP:SETDB1 and MORC2 bind MPHOSPH8 (MPP8) in HUSH complex:L1HS,L1PA2,3 heterochromatin - Homo sapiens
releaseDate	2024-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9909738] Bourc'his, Deborah, 2024-05-14 [InstanceEdit:9909756] Fernandes, Liane P, 2024-05-14
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9844057
summation	[Summation:9851266] SETDB1 bound to the HUSH complex via ATF7IP (Timms et al. 20...

Referrals

(hasEvent)

[Pathway:R-HSA-9843970] Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex

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