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Reaction
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Entries
SETDB1 in me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1 RNA trimethylates lysine-9 of histone H3 (H3K9me3)
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authored
[InstanceEdit:9843969] May, Bruce, 2023-09-11
catalystActivity
[CatalystActivity:9843992] histone H3 methyltransferase activity of me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1 RNA [nucleoplasm]
category
transition
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:9843957] May, Bruce, 2023-09-12
dbId
9844006
displayName
SETDB1 in me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1 RNA trimethylates lysine-9 of histone H3 (H3K9me3)
edited
[InstanceEdit:9843969] May, Bruce, 2023-09-11
eventOf
[Pathway:R-HSA-9843970] Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex - Homo sapiens
followingEvent
[Reaction:R-HSA-9844015] MPHOSPH8 (MPP8) in HUSH complex binds histone H3 trimethyl-lysine 9 (H3K9me3) in L1HS,L1PA2,3 heterochromatin - Homo sapiens
input
6 ×
[SimpleEntity:R-ALL-77087] AdoMet [nucleoplasm]
[Complex:R-HSA-427402] Nucleosome [nucleoplasm]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:9843984] Genome surveillance by HUSH-mediated silencing of intronless mobile elements
maxDepth
1
modified
[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name
SETDB1 in me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1 RNA trimethylates lysine-9 of histone H3 (H3K9me3)
orthologousEvent
[Reaction:R-GGA-9844006] SETDB1 in me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1 RNA trimethylates lysine-9 of histone H3 (H3K9me3) - Gallus gallus
[Reaction:R-XTR-9844006] SETDB1 in me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1 RNA trimethylates lysine-9 of histone H3 (H3K9me3) - Xenopus tropicalis
[Reaction:R-SSC-9844006] SETDB1 in me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1 RNA trimethylates lysine-9 of histone H3 (H3K9me3) - Sus scrofa
[Reaction:R-BTA-9844006] SETDB1 in me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1 RNA trimethylates lysine-9 of histone H3 (H3K9me3) - Bos taurus
[Reaction:R-CFA-9844006] SETDB1 in me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1 RNA trimethylates lysine-9 of histone H3 (H3K9me3) - Canis familiaris
[Reaction:R-RNO-9844006] SETDB1 in me3-K16-ATF7IP:SETDB1:MORC2:HUSH complex:L1 RNA trimethylates lysine-9 of histone H3 (H3K9me3) - Rattus norvegicus
output
6 ×
[SimpleEntity:R-ALL-77502] AdoHcy [nucleoplasm]
[Complex:R-HSA-5625748] Nucleosome with H3K9me3 [nucleoplasm]
precedingEvent
[Reaction:R-HSA-9843993] me3-K16-ATF7IP:SETDB1 and MORC2 bind MPHOSPH8 (MPP8) in HUSH complex:L1 RNA - Homo sapiens
releaseDate
2024-06-15
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9909738] Bourc'his, Deborah, 2024-05-14
[InstanceEdit:9909756] Fernandes, Liane P, 2024-05-14
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-9844006
summation
[Summation:9851271] SETDB1 tethered to retroelement nascent RNA via the HUSH com...
Referrals
(precedingEvent)
[Reaction:R-HSA-9844015] MPHOSPH8 (MPP8) in HUSH complex binds histone H3 trimethyl-lysine 9 (H3K9me3) in L1HS,L1PA2,3 heterochromatin
(hasEvent)
[Pathway:R-HSA-9843970] Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
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