Reactome | PSAP(195-273) forms a dimer

Schema > Reaction > Entries

PSAP(195-273) forms a dimer Show undefined attributes

authored	[InstanceEdit:9840326] Stephan, Ralf, 2023-07-17
category	binding
compartment	[Compartment:161320] lysosomal lumen
created	[InstanceEdit:9840468] Stephan, Ralf, 2023-07-19
dbId	9840488
displayName	PSAP(195-273) forms a dimer
edited	[InstanceEdit:9842093] Stephan, Ralf, 2023-08-17
eventOf	[Pathway:R-HSA-9840310] Glycosphingolipid catabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-9842115] PSAP(195-273) dimer binds PE - Homo sapiens
input	2 × [EntityWithAccessionedSequence:R-HSA-9840336] PSAP(195-273) [lysosomal lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9840458] Expression, purification, crystallization, and preliminary X-ray analysis of recombinant human saposin B [LiteratureReference:9840464] Structural analysis of saposin C and B. Complete localization of disulfide bridges [LiteratureReference:9840471] Crystal structure of saposin B reveals a dimeric shell for lipid binding
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	PSAP(195-273) forms a dimer
orthologousEvent	[Reaction:R-MMU-9840488] PSAP(195-273) forms a dimer - Mus musculus [Reaction:R-DDI-9840488] PSAP(195-273) forms a dimer - Dictyostelium discoideum [Reaction:R-CEL-9840488] PSAP(195-273) forms a dimer - Caenorhabditis elegans [Reaction:R-DME-9840488] PSAP(195-273) forms a dimer - Drosophila melanogaster [Reaction:R-GGA-9840488] PSAP(195-273) forms a dimer - Gallus gallus [Reaction:R-DRE-9840488] PSAP(195-273) forms a dimer - Danio rerio [Reaction:R-SSC-9840488] PSAP(195-273) forms a dimer - Sus scrofa [Reaction:R-BTA-9840488] PSAP(195-273) forms a dimer - Bos taurus [Reaction:R-CFA-9840488] PSAP(195-273) forms a dimer - Canis familiaris [Reaction:R-RNO-9840488] PSAP(195-273) forms a dimer - Rattus norvegicus
output	[Complex:R-HSA-9840482] PSAP(195-273) dimer [lysosomal lumen]
precedingEvent	[BlackBoxEvent:R-HSA-9840334] PSAP is cleaved - Homo sapiens
releaseDate	2023-09-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9842059] D'Eustachio, Peter, 2023-08-17
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9840488
summation	[Summation:9840495] Saposin B (PSAP(195-273)) is the only PSAP fragment that for...

Referrals

(hasEvent)	[Pathway:R-HSA-9840310] Glycosphingolipid catabolism
(precedingEvent)	[Reaction:R-HSA-9842115] PSAP(195-273) dimer binds PE