Reactome | RSV F binds TLR4:LY96:CD14

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RSV F binds TLR4:LY96:CD14 Show undefined attributes

authored	[InstanceEdit:9836254] Shamovsky, Veronica, 2023-05-24
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region [Compartment:830] viral capsid [Compartment:259388] virion membrane
created	[InstanceEdit:9836254] Shamovsky, Veronica, 2023-05-24
dbId	9836227
displayName	RSV F binds TLR4:LY96:CD14
edited	[InstanceEdit:9853009] Orlic-Milacic, Marija, 2023-11-09
eventOf	[Pathway:R-HSA-9820960] Respiratory syncytial virus (RSV) attachment and entry - Homo sapiens [Pathway:R-HSA-9833110] RSV-host interactions - Homo sapiens
input	[DefinedSet:R-HSA-166029] CD14 [plasma membrane] [Complex:R-RSY-9836527] hRSV A virion [extracellular region] [Complex:R-HSA-166050] TLR4:LY96 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9836233] Recurrent Respiratory Syncytial Virus Infection in a CD14-Deficient Patient [LiteratureReference:9836245] Respiratory syncytial virus fusion protein-induced toll-like receptor 4 (TLR4) signaling is inhibited by the TLR4 antagonists Rhodobacter sphaeroides lipopolysaccharide and eritoran (E5564) and requires direct interaction with MD-2 [LiteratureReference:181308] Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus [LiteratureReference:9837115] Host species-specific usage of the TLR4-LPS receptor complex [LiteratureReference:9837111] Role of human TLR4 in respiratory syncytial virus-induced NF-?B activation, viral entry and replication [LiteratureReference:9837100] The role of Toll-like receptor 4 versus interleukin-12 in immunity to respiratory syncytial virus [LiteratureReference:9837101] Respiratory syncytial virus prolifically infects N2a neuronal cells, leading to TLR4 and nucleolin protein modulations and RSV F protein co-localization with TLR4 and nucleolin
maxDepth	1
modified	[InstanceEdit:9964087] Stephan, Ralf, 2025-08-19
name	RSV F binds TLR4:LY96:CD14
output	[Complex:R-HSA-9836220] TLR4:LY96:CD14:RSV A virion [plasma membrane]
relatedSpecies	[Species:9717528] Human respiratory syncytial virus A
releaseDate	2023-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9852848] Bergeron, Harrison Christopher, 2023-11-03
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9836227
summation	[Summation:9836243] Respiratory syncytial virus (RSV) fusion glycoprotein (F) is...

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